---
title: Do magnesium and magnesium plus vitamin B6 reduce PMS severity?
description: Yes. Both magnesium and magnesium plus vitamin B6 reduced PMS symptoms. The combination of magnesium and B6 worked better than magnesium alone or placebo.
url: https://niyora.com/research/papers/evaluating-the-effect-of-magnesium-and-magnesium-plus-vitamin-b6-supplement-on-2010/
---

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- Do magnesium and magnesium plus vitamin B6 reduce PMS severity?

Randomised trial, 2010

# Do magnesium and magnesium plus vitamin B6 reduce PMS severity?

Yes. Both magnesium and magnesium plus vitamin B6 reduced PMS symptoms. The combination of magnesium and B6 worked better than magnesium alone or placebo.

 Moderate study design

Women in Isfahan, Iran with confirmed PMS

## What they did

Randomized trial at 10 health centers in Isfahan over 4 months total. Women were first monitored for 2 months to confirm they had PMS, then randomly assigned to one of three groups: magnesium, magnesium plus vitamin B6, or placebo. The intervention lasted 2 menstrual cycles.

## What they found

All three groups showed significant improvement in PMS severity scores. The improvement was greatest in the magnesium plus vitamin B6 group and least in the placebo group.

## What it means for you

Magnesium and especially magnesium combined with vitamin B6 may help reduce PMS. The abstract does not provide the specific numbers for how much each group improved.

3

treatment groups

2

months of baseline monitoring

2

cycles of active treatment

## About the study

Original title Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome Authors Fathizadeh N, Ebrahimi E, Valiani M et al. Journal Iranian journal of nursing and midwifery research Year 2010 Study design Randomised trial What was tested Magnesium or magnesium plus vitamin B6 for 2 menstrual cycles Open access Yes Read the paper [https://pubmed.ncbi.nlm.nih.gov/22069417/](https://pubmed.ncbi.nlm.nih.gov/22069417/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)

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