--- title: Does combining two medications treat PMS symptoms better than each one alone? description: Yes, the study found that combining mefenamic acid with sulbutiamine worked better than either medication by itself, with 66.87% symptom improvement for the c url: https://niyora.com/research/papers/evaluation-of-mefenamic-acid-and-sulbutiamine-as-monotherapy-and-as-combination-2012/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does combining two medications treat PMS symptoms better than each one alone? Study, 2012 # Does combining two medications treat PMS symptoms better than each one alone? Yes, the study found that combining mefenamic acid with sulbutiamine worked better than either medication by itself, with 66.87% symptom improvement for the combination versus 39.33% for mefenamic acid alone and 41.01% for sulbutiamine alone. Moderate study design 60 women with PMS symptoms ## What they did Researchers studied 60 women with PMS symptoms. They divided them into three groups: one group took mefenamic acid (a pain reliever), one group took sulbutiamine (a form of vitamin B1), and one group took both medications together. They measured how much each woman's PMS symptoms improved. ## What they found With mefenamic acid alone, symptom improvement was 39.33%. With sulbutiamine alone, improvement was 41.01%. When both medications were combined, improvement was 66.87%. The combination showed greater improvement than either medication taken by itself. ## What it means for you Combining these two drugs may help PMS symptoms more effectively than using either one alone. However, this was a small study and did not compare to placebo or no treatment, so we cannot be certain these improvements represent true benefit versus natural changes in symptoms. The study does not tell us about side effects or how long the benefit lasts. 60 women studied 66.87% improvement with both medications 39.33% improvement with mefenamic acid alone ## About the study Original title Evaluation of Mefenamic Acid and Sulbutiamine as Monotherapy and as Combination Therapy in Patients of Pre-Menstrual Syndrome: A Comparative Study Authors Annu Maheshwari, Arun Kumar Maria Journal Journal of Research in Medical Education & Ethics Year 2012 Study design Study Participants 60 What was tested Three treatment groups: mefenamic acid alone, sulbutiamine alone, or both together Read the paper [doi.org/10.5958/j.2231-671x.2.1.005](https://doi.org/10.5958/j.2231-671x.2.1.005) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Guideline, 2019 How should doctors treat PMS and PMDD? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Systematic review, 2013 Does Vitex (chaste tree) help PMS and PMDD symptoms? Randomised trial, 2008 Does drospirenone with ethinyl estradiol birth control help PMDD? Systematic review, 2008 What treatments work best for PMS and PMDD? Systematic review, 2007 What treatments work for premenstrual syndrome? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗