---
title: Do low progesterone and genetics explain PMS? | Niyora
description: Women with PMS have significantly lower progesterone in the luteal phase, especially those with swelling or severe symptoms. A genetic variant (PROGINS) was n
url: https://niyora.com/research/papers/evaluation-of-progesterone-and-progesterone-receptor-gene-progins-polymorphism-2020/
---

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- Do low progesterone and genetics explain PMS?

Survey study, 2020

# Do low progesterone and genetics explain PMS?

Women with PMS have significantly lower progesterone in the luteal phase, especially those with swelling or severe symptoms. A genetic variant (PROGINS) was not significantly different between women with and without PMS.

 Early or limited evidence

50 women with PMS and 25 women without PMS, reproductive age

## What they did

Cross-sectional study. Researchers measured progesterone in blood twice during the menstrual cycle (in the follicular and luteal phases) in 50 women with PMS and 25 without. They also tested for a genetic variant (PROGINS T1T2).

## What they found

Women with PMS, especially those with edematous (swelling) and severe forms, had low progesterone in the luteal phase. The PROGINS genetic variant showed no significant differences between women with and without PMS.

## What it means for you

Low progesterone may play a role in PMS, particularly in swelling and severe types. The genetic variant studied does not appear to be a major factor. This is a very small study with only 50 women with PMS, limiting confidence in the findings.

50

women with PMS

25

women without PMS (control)

p<0.05

low progesterone in luteal phase

## About the study

Original title Evaluation of progesterone and progesterone receptor gene PROGINS polymorphism in the development of some forms of premenstrual syndrome Authors Lyudmyla V. Pakharenko Journal Reproductive health of woman Year 2020 Study design Survey study Participants 50 What was tested None. This measured progesterone levels and tested for a genetic variant. Open access Yes Read the paper [doi.org/10.30841/2708-8731.1.2020.471241](https://doi.org/10.30841/2708-8731.1.2020.471241) Original abstract

One of the most common neuroendocrine syndromes in gynecology is premenstrual syndrome (PMS). The article is devoted to study of pro-gesterone level and frequency of polymorphic variants T1T2 of progesterone receptor gene PROGINS, as well as their possible relationship in patients with various forms of PMS. The object of the study were 50 women of reproductive age with diagnosis of PMS, including 25 women with edematous form of the disease, 25 – with neuropsychical form. Mild form of disease had 25 women, severe form – also 25 persons. Control group consisted of 25 women without diagnosis of PMS. Progesterone level was determined in blood serum twice in the first and second phase of menstrual cycle. Polymorphism T1T2 of progesterone gene receptor PROGINS was studied using polymerase chain reaction.We found hypoprogesteronemia of luteal phase of menstrual cycle in women with PMS, especially pronounced in persons with edematous and severe forms of the disease (p 0.05)

Reproduced under CC-BY.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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