---
title: Does Echium amoenum and Foeniculum vulgare combination reduce PMS symptoms?
description: Yes. The herbal combination taken in the second half of the menstrual cycle significantly improved PMS symptoms and quality of life over two months.
url: https://niyora.com/research/papers/evaluation-of-the-effect-of-i-foeniculum-vulgare-i-fruit-and-i-echium-amoenum-i-2024/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does Echium amoenum and Foeniculum vulgare combination reduce PMS symptoms?

Randomised trial, 2024

# Does Echium amoenum and Foeniculum vulgare combination reduce PMS symptoms?

Yes. The herbal combination taken in the second half of the menstrual cycle significantly improved PMS symptoms and quality of life over two months.

 Strong study design

80 women with PMS

## What they did

Eighty women with PMS were randomly assigned to either treatment or placebo in a triple-blinded trial. The treatment group took Echium amoenum 2 g per day and Foeniculum vulgare 1 g per day during the second two weeks of their cycle for two consecutive cycles. Symptoms and quality of life were measured using questionnaires.

## What they found

All PMS symptom categories showed significant improvement between groups at one and two months (p<0.05). Bleeding volume increased significantly in the treatment group at two months (p<0.05). Quality of life improved significantly in almost all areas except emotional limitations (p=0.07).

## What it means for you

The herbal combination reduced PMS symptoms and improved quality of life. However, it also increased menstrual bleeding, which could be a concern for some women. Long-term safety has not been studied.

80

women with PMS

2 g

daily Echium amoenum

2

consecutive menstrual cycles of treatment

## About the study

Original title Evaluation of the effect of <i>Foeniculum vulgare</i> fruit and <i>Echium amoenum</i> flower combination on the severity of physical and psychological symptoms of premenstrual syndrome Authors Motevalli Haghi SS, Sahebkar A, Jamali J et al. Journal Avicenna journal of phytomedicine Year 2024 Study design Randomised trial Participants 80 What was tested Echium amoenum 2 g per day and Foeniculum vulgare 1 g per day in the second two weeks of the cycle vs placebo Open access Yes Read the paper [doi.org/10.22038/ajp.2024.24208](https://doi.org/10.22038/ajp.2024.24208) Original abstract

Objective: Echium amoenum (EA) and Foeniculum vulgare (FV) might be beneficial for the management of Premenstrual syndrome (PMS) due to their possible effects on sex hormones and neurotransmitters such as serotonin. This study aimed to investigate the effect of a combination of Echium and Fennel on the severity of physical and psychological symptoms of PMS. Materials and methods: This triple-blinded, randomized, controlled trial was conducted on 80 women. The subjects were assigned to two groups of intervention (receiving EA 2 g/day and FV 1 g/day, in the second two weeks of the cycle, in two consecutive cycles) and placebo control. The data collection tools included the PSST, DRSP, and SF36 questionnaires. Results: Between-group differences in all subscales of DRSP were significant at one- and two-month time points (p<0.05). Bleeding volume was significantly increased in the intervention group, compared to the placebo group, two months after the intervention (p<0.05). Between-group comparison of the changes demonstrated significant differences in all subscales of SF36, except for limitations in usual role activities due to emotional problems (p=0.07). Conclusion: Consumption of EA and FV combination improved the quality of life in women with PMS and exerted favorable changes in PMS symptoms.

Reproduced under CC-BY.

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

Which traditional Chinese medicine treatments work best for PMS?

Randomised trial, 2025

Do essential oils reduce PMS symptoms?

Randomised trial, 2025

Which is more effective for PMS - Vitagnus, soy, or both together?

Randomised trial, 2025

Does the PMSoff supplement help PMS and PMDD symptoms?

Randomised trial, 2024

Is Jiawei Xiaoyao pill effective and safe for treating premenstrual syndrome?

Randomised trial, 2024

Is Ganyushu Granule effective and safe for premenstrual syndrome?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗