--- title: Does a flavonoid supplement help with premenstrual fluid retention and leg swelling? description: The supplement improved women's sense of leg health but did not reduce actual leg swelling. Results for fluid retention approached but did not reach significa url: https://niyora.com/research/papers/flavonoid-supplement-improves-leg-health-and-reduces-fluid-retention-in-pre-2004/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a flavonoid supplement help with premenstrual fluid retention and leg swelling? Randomised trial, 2004 # Does a flavonoid supplement help with premenstrual fluid retention and leg swelling? The supplement improved women's sense of leg health but did not reduce actual leg swelling. Results for fluid retention approached but did not reach significance. Moderate study design 30 pre-menopausal women with premenstrual fluid retention ## What they did A double-blind, placebo-controlled pilot study where 30 pre-menopausal women with premenstrual fluid retention received either a daily flavonoid extract (320 mg) or placebo for 4 menstrual cycles. Leg girth was measured and women reported symptoms. ## What they found Significant improvement in subjective leg health scores with flavonoid treatment compared to placebo (p=0.013). Improvement in reported fluid retention nearly reached significance (p=0.066). No significant changes were noted in actual leg girth measurements. ## What it means for you Women reported feeling their legs were healthier after the supplement, but leg measurements did not actually change. This was a small pilot study, so larger studies are needed. It is unclear whether the subjective feeling of improvement has practical value. 18 Women receiving flavonoid treatment 12 Women receiving placebo 4 Menstrual cycles in study ## About the study Original title Flavonoid supplement improves leg health and reduces fluid retention in pre-menopausal women in a double-blind, placebo-controlled study Authors Christie S, Walker AF, Hicks SM et al. Journal Phytomedicine : international journal of phytotherapy and phytopharmacology Year 2004 Study design Randomised trial Participants 18 What was tested Daily flavonoid extract (320 mg) vs placebo Read the paper [doi.org/10.1078/0944-7113-00347](https://doi.org/10.1078/0944-7113-00347) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Guideline, 2024 How should Xiangshao Granules be prescribed for premenstrual tension syndrome? Systematic review, 2023 Does saffron help with PMS, labor pain, and menopause symptoms? Review, 2017 Can combining different types of treatments help PMS more than using one approach alone? Randomised trial, 2006 Do herbal remedies help with PMS, pregnancy nausea, or hot flushes? Randomised trial, 2006 What herbs and dietary supplements have evidence for treating premenstrual syndrome? Review, 2021 Do herbal products help with PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗