---
title: Does fluoxetine reduce PMS mood symptoms? | Niyora
description: Yes. The study found that fluoxetine reduced premenstrual feelings of sadness, tension, and irritability.
url: https://niyora.com/research/papers/fluoxetine-as-a-treatment-for-pms-1995/
---

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- Does fluoxetine reduce PMS mood symptoms?

Randomised trial, 1995

# Does fluoxetine reduce PMS mood symptoms?

Yes. The study found that fluoxetine reduced premenstrual feelings of sadness, tension, and irritability.

 Moderate study design

313 women with premenstrual syndrome

## What they did

313 women with PMS were randomly assigned to receive either 20 mg or 60 mg of fluoxetine (an antidepressant) in a double-blind trial.

## What they found

Fluoxetine reduced premenstrual symptoms of sadness, tension, and irritability.

## What it means for you

An antidepressant may help with PMS mood and tension symptoms. Main limit: the abstract is incomplete, so the full results and which dose was more effective are not clear.

313

women randomized

20 mg

fluoxetine low dose

60 mg

fluoxetine high dose

## About the study

Original title Fluoxetine as a Treatment for PMS Authors Peter Roy‐Byrne Journal Journal watch Year 1995 Study design Randomised trial Participants 313 What was tested Fluoxetine 20 mg or 60 mg Read the paper [doi.org/10.1056/jp199507010000005](https://doi.org/10.1056/jp199507010000005)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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