--- title: Do hormonal changes in obese women cause worse PMS, and can medications help? description: Yes, obese women with PMS had significantly higher stress hormone levels than healthy women, and a combination treatment of medications, diet, and exercise si url: https://niyora.com/research/papers/hormonal-changes-aggravate-premenstrual-tension-syndrome-in-obese-women-and-2024/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do hormonal changes in obese women cause worse PMS, and can medications help? Randomised trial, 2024 # Do hormonal changes in obese women cause worse PMS, and can medications help? Yes, obese women with PMS had significantly higher stress hormone levels than healthy women, and a combination treatment of medications, diet, and exercise significantly reduced these hormones and PMS symptoms. Moderate study design 60 obese women with premenstrual tension syndrome in Iran (ages 18-48) and age-matched healthy controls ## What they did Randomized controlled trial with 60 obese women with premenstrual tension syndrome divided into age groups (18-39 and 40-48 years), compared to age-matched healthy controls. Blood levels of stress hormones (adrenaline and noradrenaline) were measured. The treatment group received combined therapy including Metformin, a diuretic, calorie-restricted diet, walking, and vitamin supplementation. ## What they found Obese women with PMS had significantly higher serum adrenaline and noradrenaline levels compared to the control group. Combined treatment significantly reduced these stress hormones and improved symptoms of headache, backache, and stomach bloating. ## What it means for you Obesity may worsen PMS by raising stress hormone levels, and combination treatment with medication, diet, and exercise can help normalize these hormones and reduce symptoms. This study only included obese women, so findings may not apply to non-obese women with PMS. 60 obese women with PMS 18-48 age range of participants 3 PMS symptoms treated (headache, backache, bloating) ## About the study Original title Hormonal changes aggravate premenstrual tension syndrome in obese women and beneficial roles of combined pharmacological therapies: A randomized controlled trial Authors Hytham Mahmoud Abdel-Latif, Amal Yaseen Zaman, Rawan Bafail et al. Journal SVU-International Journal of Medical Sciences Year 2024 Study design Randomised trial Participants 60 What was tested Combined therapy: Metformin, Amiloride/Hydrochlorothiazide, calorie-restricted diet, walking, and Vitazinc or Royal vitamin G Open access Yes Read the paper [doi.org/10.21608/svuijm.2024.304506.1933](https://doi.org/10.21608/svuijm.2024.304506.1933) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2023 Does PMS affect school performance and relationships in female medical students? Non-randomised trial, 1983 Do drugs that block prostaglandins help PMS? Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Survey study, 1994 How many different ways do researchers measure PMS in clinical trials? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗