---
title: How do hormones affect both migraines and mood? | Niyora
description: Estrogen affects both mood and migraines through serotonin and the trigeminal nerve system. Keeping estrogen stable with hormonal treatment may help both prob
url: https://niyora.com/research/papers/hormone-related-migraine-headaches-and-mood-disorders-treatment-with-estrogen-2017/
---

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- How do hormones affect both migraines and mood?

Survey study, 2017

# How do hormones affect both migraines and mood?

Estrogen affects both mood and migraines through serotonin and the trigeminal nerve system. Keeping estrogen stable with hormonal treatment may help both problems.

 Early or limited evidence

Women with hormone-related mood disorders and migraines (review article, not a specific study)

## What they did

The authors reviewed scientific literature on how estrogen, serotonin, and the trigeminal nerve system interact. They described clinical examples from treating women during reproductive transitions like menopause when estrogen changes.

## What they found

Estrogen, serotonin, and the trigeminal nerve system are interconnected. When estrogen declines (such as before menstruation), this can trigger both mood symptoms and migraines through these shared pathways.

## What it means for you

Women with both hormone-related mood disorders and migraines may benefit from hormonal treatments that stabilize estrogen, which could help both symptoms. The main limitation is this is a review article describing how the system works, not a clinical study testing whether this approach works.

## About the study

Original title Hormone-Related Migraine Headaches and Mood Disorders: Treatment with Estrogen Stabilization Authors Warnock JK, Cohen LJ, Blumenthal H et al. Journal Pharmacotherapy Year 2017 Study design Survey study What was tested Estrogen stabilization through hormonal treatment Read the paper [doi.org/10.1002/phar.1876](https://doi.org/10.1002/phar.1876)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2023

What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?

Guideline, 2021

How should migraine be managed in women, particularly menstrual migraine?

Review, 2019

How does the menstrual cycle affect migraine in women?

Survey study, 2008

How common is menstrual migraine, and does pregnancy affect it?

Review, 2003

Does bipolar disorder affect women differently than men?

Survey study, 2011

Do hormones affect types of headaches other than migraines?

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