---
title: Do women with mood symptoms linked to their menstrual cycle have different thyroid hormone levels?
description: Yes. Women with menstrually related mood symptoms had different thyroid hormone patterns, including faster conversion of one hormone and lower levels of anoth
url: https://niyora.com/research/papers/hypothalamic-pituitary-thyroid-axis-function-in-women-with-a-menstrually-related-2012/
---

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- Do women with mood symptoms linked to their menstrual cycle have different thyroid hormone levels?

Case-control study, 2012

# Do women with mood symptoms linked to their menstrual cycle have different thyroid hormone levels?

Yes. Women with menstrually related mood symptoms had different thyroid hormone patterns, including faster conversion of one hormone and lower levels of another. These patterns were linked to worse premenstrual symptoms.

 Moderate study design

57 women with menstrually related mood disorder and 52 without; 23 and 18 had sexual abuse histories

## What they did

Researchers measured thyroid hormones in 57 women with mood symptoms linked to their menstrual cycle and 52 without these symptoms. Some women in each group had experienced sexual abuse (23 in the mood symptom group, 18 in the other).

## What they found

Women with menstrually related mood symptoms had higher T3-to-T4 conversion ratios and lower T4 levels. These thyroid patterns linked to worse premenstrual symptoms. Sexual abuse history was linked to higher TSH. In women with mood symptoms, sexual abuse linked to higher T3; without mood symptoms, linked to lower T3.

## What it means for you

Thyroid hormones may play a role in menstrually related mood symptoms. Sexual abuse history changes thyroid hormones differently depending on whether someone has these mood symptoms. This complex area needs more research to understand.

57

with menstrually related mood disorder

52

without mood symptoms

23 and 18

with sexual abuse histories

## About the study

Original title Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: association with histories of sexual abuse Authors Bunevicius A, Leserman J, Girdler SS Journal Psychosomatic medicine Year 2012 Study design Case-control study Participants 52 Open access Yes Read the paper [doi.org/10.1097/psy.0b013e31826c3397](https://doi.org/10.1097/psy.0b013e31826c3397)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/)

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