--- title: Does Nigella sativa reduce PMS symptoms in women? | Niyora description: Yes, Nigella sativa supplements reduced PMS symptoms and increased estrogen levels in women with moderate to severe PMS. This is a well-designed study, but th url: https://niyora.com/research/papers/i-nigella-sativa-i-seeds-ease-severity-of-premenstrual-syndrome-in-women-a-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does Nigella sativa reduce PMS symptoms in women? Randomised trial, 2025 # Does Nigella sativa reduce PMS symptoms in women? Yes, Nigella sativa supplements reduced PMS symptoms and increased estrogen levels in women with moderate to severe PMS. This is a well-designed study, but the sample size is not reported in the abstract. Moderate study design Women with moderate to severe PMS ## What they did Randomized double-blind placebo-controlled trial. Women with moderate to severe PMS took 2 capsules of Nigella sativa or placebo once daily for 2 menstrual cycles, with daily symptom tracking. ## What they found After 2 months, women taking Nigella sativa had significantly higher estrogen levels and significantly lower PMS scores compared to placebo. ## What it means for you Nigella sativa may help reduce PMS by increasing estrogen, but we don't know the study size or if benefits last beyond 2 months. Larger studies are needed. 2 capsules Daily dose 2 months Treatment duration p < 0.05 Statistical significance ## About the study Original title Nigella sativa Seeds Ease Severity of Premenstrual Syndrome in Women: A Randomized, Double-Blinded, Placebo-Controlled Study Authors Afrin F, Neela MM, Islam A et al. Journal BioMed research international Year 2025 Study design Randomised trial What was tested Nigella sativa supplement, 2 capsules once daily Open access Yes Read the paper [doi.org/10.1155/bmri/9811666](https://doi.org/10.1155/bmri/9811666) Original abstract Background: Premenstrual syndrome (PMS) significantly affects women's quality of life, with fluctuations in estrogen levels implicated in symptom severity. Lower estrogen levels during the premenstrual phase may contribute to mood swings, anxiety, and fatigue. Nigella sativa ( NS ) has been examined as a potential alternative therapeutic approach for various diseases. Therefore, in the current experiment, we aimed to investigate the impact of NS on serum estradiol levels and the severity of PMS symptoms in women. Methods: This was a randomized, double-blind, placebo-controlled clinical trial. Participants with moderate to severe PMS were identified using a Premenstrual Symptoms Screening Tool (PSST) questionnaire and randomly allocated to the placebo or treatment groups. Two capsules were consumed once a day for two menstrual cycles, and the severity of symptoms in the participants was monitored daily during the intervention, employing the daily record of severity of problems (DRSP). Results: At baseline, there were no significant differences ( p > 0.05) in serum estradiol levels and total average PMS scores between the two groups. In comparison, after 2 months of NS supplement, serum estradiol concentrations were significantly ( p NS in reducing the severity of PMS. This could be achieved by increasing serum estradiol concentration in premenstrual women with PMS. Additionally, NS can provide anti-inflammatory and potential hormonal and antioxidant support, helping to reduce symptoms of PMS. Therefore, NS is an alternative or complementary method deserving further investigation based on scientific evidence to clarify its role in PMS treatment. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2012 What non-hormonal medications and therapies help severe PMS and PMDD? Survey study, 2025 Can a plant-based supplement reduce PMS symptoms? Cohort study, 2010 How do anxiety disorders differ across different life stages? Systematic review, 2021 Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating? Survey study, 2020 What symptoms best predict whether PMDD will seriously affect daily life? Review, 2015 What do we know about PMS and PMDD and how are they treated? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗