---
title: Do PMS symptoms make multiple sclerosis symptoms worse? | Niyora
description: Yes. Multiple sclerosis symptoms got worse during the premenstrual period, especially pain and fatigue. But this very small study needs to be confirmed with l
url: https://niyora.com/research/papers/impact-of-premenstrual-syndrome-on-multiple-sclerosis-symptoms-in-adult-female-a-2021/
---

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- Do PMS symptoms make multiple sclerosis symptoms worse?

Survey study, 2021

# Do PMS symptoms make multiple sclerosis symptoms worse?

Yes. Multiple sclerosis symptoms got worse during the premenstrual period, especially pain and fatigue. But this very small study needs to be confirmed with larger research.

 Early or limited evidence

40 women aged 20-35 with multiple sclerosis and PMS, BMI less than 30, from El-Dokki, Egypt

## What they did

Cross-sectional comparative study of 40 women with multiple sclerosis and PMS (aged 20-35, BMI less than 30). Assessed them on normal menstrual days and premenstrual days using symptom severity scales and pain scales.

## What they found

During premenstrual period: functional system score increased significantly (p=0.006), fatigue severity scale increased significantly (p=0.0001), pain intensity increased significantly (p=0.0001).

## What it means for you

Women with multiple sclerosis should know symptoms may worsen before their period, especially pain and fatigue. Very limited because only 40 women in one location, so larger research needed.

40

Number of women studied

p=0.0001

Fatigue and pain significance

p=0.006

Functional score significance

## About the study

Original title Impact of premenstrual syndrome on multiple sclerosis symptoms in adult female: a retrospective cross-sectional study Authors Yosra Elhussein IBRAHIM, Soheir M. El‐Kosery, Mohamed Abo Elainin et al. Journal Journal of Life Science and Biomedicine Year 2021 Study design Survey study What was tested None Open access Yes Read the paper [doi.org/10.51145/jlsb.2021.13](https://doi.org/10.51145/jlsb.2021.13)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Fatigue and energy](https://niyora.com/research/topics/symptom-fatigue/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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