---
title: Does taking extra nefazodone before your period help depression that worsens premenstrually?
description: Yes, all 3 women in the study showed significant improvement with extra nefazodone taken before their period, but not with placebo. However, the study was ver
url: https://niyora.com/research/papers/increased-premenstrual-dosing-of-nefazodone-relieves-premenstrual-magnification-2002/
---

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- Does taking extra nefazodone before your period help depression that worsens premenstrually?

Randomised trial, 2002

# Does taking extra nefazodone before your period help depression that worsens premenstrually?

Yes, all 3 women in the study showed significant improvement with extra nefazodone taken before their period, but not with placebo. However, the study was very small.

 Early or limited evidence

3 women with premenstrual magnification of depression

## What they did

Three women with depression that worsens premenstrually were given either extra nefazodone or placebo before their expected menstrual period in a double-blind crossover design. The study lasted 6 months, with treatment alternating each cycle.

## What they found

All 3 subjects showed significant improvement for the months in which they received nefazodone supplements, but not when given placebo.

## What it means for you

While premenstrual dose increases of nefazodone appear clinically promising, this study included only 3 women, so we cannot be confident the results would apply to others. Much more research is needed.

3

Number of women

6 months

Study duration

## About the study

Original title Increased premenstrual dosing of nefazodone relieves premenstrual magnification of depression Authors Miller MN, Miller BE, Chinouth R et al. Journal Depression and anxiety Year 2002 Study design Randomised trial Participants 3 What was tested Extra nefazodone taken premenstrually Open access Yes Read the paper [doi.org/10.1002/da.1086](https://doi.org/10.1002/da.1086)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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