---
title: What medicines work best for treating moderate to severe premenstrual syndrome?
description: For mild to moderate PMS, the first approach should be diet, exercise, and nutritional supplements. For severe cases, medications like danazol, estrogen impla
url: https://niyora.com/research/papers/indications-for-drug-therapy-in-premenstrual-syndrome-patients-1987/
---

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- What medicines work best for treating moderate to severe premenstrual syndrome?

Review, 1987

# What medicines work best for treating moderate to severe premenstrual syndrome?

For mild to moderate PMS, the first approach should be diet, exercise, and nutritional supplements. For severe cases, medications like danazol, estrogen implants, or progesterone at 300 mg per day can be tried, though evidence for some is still limited.

 Early or limited evidence

Women with mild to severe premenstrual syndrome

## What they did

This was a review of medication treatment options for different levels of PMS severity.

## What they found

Progesterone alone did not work better than placebo in most studies, except one study using oral micronized progesterone at 300 mg per day. Other options with some evidence include danazol, estrogen implants, depomedroxyprogesterone acetate, and prostaglandin inhibitors.

## What it means for you

Treatment should match symptom severity. A major limitation is that much evidence comes from small studies and some treatments need further testing by other researchers.

300 mg/day

Dose of oral micronized progesterone that showed benefit in one study

## About the study

Original title Indications for drug therapy in premenstrual syndrome patients Authors Chihal HJ Journal The Journal of reproductive medicine Year 1987 Study design Review What was tested Various medications including progesterone, danazol, estrogen, and others Read the paper [https://pubmed.ncbi.nlm.nih.gov/2956417/](https://pubmed.ncbi.nlm.nih.gov/2956417/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)

Research tells you what helps on average. Niyora helps on the day it hits.

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## Related studies

Systematic review, 2007

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Case report, 2012

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Do hysterectomy or hormonal IUDs reduce premenstrual symptoms in women with heavy periods?

Review, 2012

Does stopping ovulation help premenstrual symptoms?

Review, 1991

Does progesterone or stopping your period treat PMS?

Cohort study, 1990

Does long-term estradiol implant therapy help PMS symptoms?

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