--- title: Does hormone replacement therapy change serotonin receptors in postmenopausal women? description: No significant change was found in serotonin transporter or 5-HT2A receptor binding with hormone treatment in healthy postmenopausal women, though depressed w url: https://niyora.com/research/papers/influence-of-postmenopausal-hormone-replacement-therapy-on-platelet-serotonin-2001/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does hormone replacement therapy change serotonin receptors in postmenopausal women? Randomised trial, 2001 # Does hormone replacement therapy change serotonin receptors in postmenopausal women? No significant change was found in serotonin transporter or 5-HT2A receptor binding with hormone treatment in healthy postmenopausal women, though depressed women showed a more pronounced effect. Moderate study design 23 postmenopausal women with climacteric symptoms ## What they did Researchers studied 23 postmenopausal women in a double-blind randomised crossover study. Each woman received 2 mg estradiol continuously during 28-day cycles. In the last 14 days of each cycle, she received either 10 mg medroxyprogesterone, 1 mg norethindrone, or placebo. Blood samples were taken before treatment and during the last week of each treatment to measure serotonin receptor binding. ## What they found There was no change in serotonin transporter binding or 5-HT2A receptor binding with any hormone treatment in the overall group. However, in women who were depressed, the decrease in 5-HT2A receptor binding during treatment was significantly more pronounced than in non-depressed women (P less than .05). ## What it means for you Hormone replacement therapy does not change serotonin receptors in healthy postmenopausal women, but may work differently in depressed women. This is a laboratory measurement of receptor binding, not a study of whether hormone therapy helps mood symptoms. Main limit: this only studied postmenopausal women, not women of reproductive age with PMS. 23 postmenopausal women 2 mg daily estradiol dose P<.05 significance in depressed subgroup ## About the study Original title Influence of postmenopausal hormone replacement therapy on platelet serotonin uptake site and serotonin 2A receptor binding Authors Wihlbäck AC, Sundström-Poromaa I, Allard P et al. Journal Obstetrics and gynecology Year 2001 Study design Randomised trial What was tested Estradiol 2 mg daily plus medroxyprogesterone, norethindrone, or placebo Read the paper [doi.org/10.1016/s0029-7844(01)01461-2](https://doi.org/10.1016/s0029-7844(01)01461-2) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)[Athletes and sport](https://niyora.com/research/topics/life-area-athletes/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2012 How is PMS diagnosed and treated, especially in women approaching menopause? Systematic review, 2007 What treatments work for premenstrual syndrome? Review, 2020 Does pollen extract help with menopausal symptoms and premenstrual syndrome? Non-randomised trial, 2014 Does hormone therapy help women with depression linked to periods and menopause? Review, 2010 Is the menopause transition a risky time for depression to develop? Study, 2001 What are the current treatment options for PMS and PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗