---
title: Is low serotonin sensitivity a permanent trait in PMDD? | Niyora
description: Women with PMDD showed blunted serotonin responses during their follicular phase, suggesting low serotonin sensitivity may be a constant trait rather than onl
url: https://niyora.com/research/papers/is-5ht1a-receptor-subsensitivity-a-trait-marker-for-late-luteal-phase-dysphoric-1993/
---

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- Is low serotonin sensitivity a permanent trait in PMDD?

Cohort study, 1993

# Is low serotonin sensitivity a permanent trait in PMDD?

Women with PMDD showed blunted serotonin responses during their follicular phase, suggesting low serotonin sensitivity may be a constant trait rather than only occurring before the period.

 Early or limited evidence

7 women with PMDD and 7 healthy control women

## What they did

7 women with PMDD and 7 control women received a serotonin challenge test (buspirone) during their follicular phase. Researchers measured prolactin responses to assess serotonin system function.

## What they found

Women with PMDD had blunted prolactin responses to buspirone during the follicular phase.

## What it means for you

Low serotonin sensitivity may be an ongoing feature of PMDD, but this was a very small pilot study that needs confirmation.

7

Women per group

Follicular

Phase tested

## About the study

Original title Is 5HT1A receptor subsensitivity a trait marker for late luteal phase dysphoric disorder? A pilot study Authors Yatham LN Journal Canadian journal of psychiatry. Revue canadienne de psychiatrie Year 1993 Study design Cohort study What was tested Buspirone serotonin challenge test Read the paper [doi.org/10.1177/070674379303801007](https://doi.org/10.1177/070674379303801007)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

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Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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What treatments work best for PMS and PMDD?

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Do women with bipolar disorder on mood-stabilizing medication experience premenstrual symptom worsening?

Review, 2002

What treatments work for PMDD?

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