---
title: Does a combination of isoxsuprine, acetaminophen and caffeine help period pain and premenstrual tension?
description: The drug combination was effective in 95 percent of women with premenstrual tension and 92.5 percent with period pain. This is an older study that doesn't cle
url: https://niyora.com/research/papers/isoxsuprine-in-primary-dysmenorrhoea-its-effectiveness-in-premenstrual-tension-1975/
---

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- Does a combination of isoxsuprine, acetaminophen and caffeine help period pain and premenstrual tension?

Randomised trial, 1975

# Does a combination of isoxsuprine, acetaminophen and caffeine help period pain and premenstrual tension?

The drug combination was effective in 95 percent of women with premenstrual tension and 92.5 percent with period pain. This is an older study that doesn't clearly show placebo comparison.

 Moderate study design

80 women: 40 with premenstrual tension and 40 with primary period pain

## What they did

80 women were divided into 2 groups: 40 with premenstrual tension and 40 with primary period pain. They received a randomized, double-blind combination of isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg.

## What they found

95 percent of women with premenstrual tension and 92.5 percent with period pain had excellent or very good response. Overall effectiveness was 93.75 percent.

## What it means for you

This combination appears effective for both premenstrual tension and period pain. Main limitations: published in 1975, so it is older, and the abstract doesn't clearly show how results compared to placebo.

80

total women

95

percent response for premenstrual tension

92.5

percent response for period pain

## About the study

Original title Isoxsuprine in primary dysmenorrhoea. Its effectiveness in premenstrual tension Authors Gallegos-Torres J, Flores-Mercado F Journal The Journal of international medical research Year 1975 Study design Randomised trial Participants 80 What was tested Isoxsuprine 10 mg, acetaminophen 250 mg and caffeine 30 mg Read the paper [doi.org/10.1177/030006057500300309](https://doi.org/10.1177/030006057500300309)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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