--- title: Can nutrients help PMS by regulating multiple body systems? | Niyora description: The paper proposes a theoretical framework suggesting nutrients could work across brain, hormone, blood vessel, and metabolic systems to help PMS. No evidence url: https://niyora.com/research/papers/keyora-integrative-nutritional-pharmacology-of-neuroendocrinevascularmetabolic-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can nutrients help PMS by regulating multiple body systems? Randomised trial, 2025 # Can nutrients help PMS by regulating multiple body systems? The paper proposes a theoretical framework suggesting nutrients could work across brain, hormone, blood vessel, and metabolic systems to help PMS. No evidence is presented. This is a conceptual proposal requiring clinical trials. Early or limited evidence Not a clinical study (theoretical framework) ## What they did Developed a theoretical framework called the Neuro-Endocrine-Vascular-Metabolic (NEVM) model to explain how nutrients might regulate interconnected biological systems involved in PMS, anxiety, depression, and sleep problems. ## What they found The framework maps three interconnected regulation axes: brain-hormone control, blood vessel-metabolic control, and serotonin-sleep-stress control. Proposes nutrients like magnesium, selenium, vitamin E, and B-complex could work across these axes to restore balance. ## What it means for you This is a theoretical model, not a clinical study with actual evidence. It proposes a new way of thinking about treating PMS by working on multiple systems together rather than single pathways. Clinical trials would be needed to test whether this approach works. 3 interconnected regulatory axes in NEVM model ## About the study Original title Keyora Integrative Nutritional Pharmacology of Neuro–Endocrine–Vascular–Metabolic Regulation: Mechanistic Framework and Clinical Applications in Emotional, Sleep, and Hormonal Dysregulation Authors Jin, Xu Journal OSF Preprints (OSF Preprints) Year 2025 Study design Randomised trial What was tested Conceptual framework for nutritional supplementation across multiple physiological systems Open access Yes Read the paper [doi.org/10.17605/osf.io/j6c8y](https://doi.org/10.17605/osf.io/j6c8y) Original abstract 1. Background and Rationale Emotional, endocrine, and metabolic disorders—ranging from menopausal transition and Premenstrual Syndrome (PMS) to anxiety, depression, and circadian misalignment—share a unified biological foundation: the loss of synchronization among the neural, hormonal, vascular, and metabolic systems. Conventional pharmacological approaches often target single molecules or pathways, failing to restore the system-level coherence required for long-term stability. Integrative Nutritional Pharmacology redefines this paradigm by viewing nutrients not as isolated supplements but as signal-modulating agents that recalibrate feedback loops across multiple physiological axes. Within this framework, nutritional compounds are mapped according to their receptor selectivity, mitochondrial and endothelial activation potential, and neurotransmitter coupling capacity—forming an evidence-based model of multi-axis homeostatic reconstruction. 2. Conceptual Framework The project proposes a Neuro–Endocrine–Vascular–Metabolic (NEVM) model, conceptualized as a closed-loop regulatory network composed of three interlinked axes: Axis I – Neuro–Endocrine Regulation: Receptor-selective modulation (e.g., estrogen receptor-β and G-protein–coupled pathways) restoring hypothalamic–pituitary feedback and hormonal rhythmicity. Axis II – Neurovascular–Metabolic Regulation: Enhancement of mitochondrial bioenergetics, nitric oxide–endothelial signaling, and Nrf2–NF-κB redox balance to optimize energy metabolism and vascular communication. Axis III – Serotonin–Sleep–Stress Regulation: Upstream precursor supplementation and neurotransmitter coupling (5-HT–GABA–melatonin network) to realign emotional and circadian stability. Together, these axes form an integrated systems pharmacology model, enabling coordinated restoration of neurochemical balance, vascular function, and metabolic resilience. 3. Mechanistic Innovation Unlike traditional reductionist approaches, this framework emphasizes cross-axis coupling and feedback coherence: - Signal Network Integration: Linking receptor-level activation (ER-β, GPER1) with intracellular cascades (AMPK–PGC-1α, PI3K–AKT–eNOS, Nrf2–NF-κB). - Multi-Organ Synchronization: Harmonizing brain–endocrine–vascular–metabolic circuits through adaptive bioenergetic regulation. - Nutrient Synergy Logic: Mapping how complementary micronutrients (e.g., magnesium, selenium, vitamin E, B-complex) reinforce primary signaling nodes to achieve multi-dimensional stability. This mechanistic fusion reflects a transition from single-pathway activation to systemic re-synchronization, establishing a new direction for nutritional pharmacology. 4. Research Scope and Applications This project integrates translational evidence from molecular studies, randomized clinical trials, and systems modeling to outline how nutrient-based interventions can reconstruct physiological feedback loops in conditions such as: - Menopausal Syndrome and Estrogen-Dominant Disorders - Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) - Anxiety, Depression, and Stress-Related Disorders - Insomnia and Circadian Rhythm Disruption - Metabolic Syndrome and Neuro-Metabolic Fatigue The overarching objective is to demonstrate that multi-axis nutritional modulation can achieve system-level homeostasis comparable to pharmacological efficacy but with superior biocompatibility and safety. 5. Expected Outcomes - Establishment of a validated multi-axis regulatory framework for nutritional pharmacology. - Development of cross-condition intervention strategies guided by shared mechanistic signatures. - Formation of a translational bridge between molecular nutrition, clinical evidence, and applied formulation design. - Contribution to open scientific discourse on the systems biology foundation of nutrient therapeutics. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin E](https://niyora.com/research/topics/treatment-vitamin-e/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2025 Could taking a combination of vitamins and minerals help with PMS and PMDD symptoms? Randomised trial, 2025 Can soy isoflavone supplements help with PMS and PMDD symptoms? Survey study, 2026 What dietary, lifestyle, and psychological factors are associated with PMS in young women? Review, 2023 Can herbs and supplements help with PMS symptoms? Survey study, 2022 How common are PMS and PMDD? Are stress, anxiety, depression, and sleep problems related to them? Survey study, 2026 Is PMDD linked to sleep problems, diet, and academic stress in female medical students? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗