--- title: Does taking a specific bacteria supplement help with premenstrual emotional symptoms? description: Taking Lactobacillus paragasseri OLL2809 for three menstrual cycles reduced premenstrual irritability and improved energy and activity levels compared to plac url: https://niyora.com/research/papers/lactobacillus-paragasseri-oll2809-improves-premenstrual-psychological-symptoms-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does taking a specific bacteria supplement help with premenstrual emotional symptoms? Randomised trial, 2023 # Does taking a specific bacteria supplement help with premenstrual emotional symptoms? Taking Lactobacillus paragasseri OLL2809 for three menstrual cycles reduced premenstrual irritability and improved energy and activity levels compared to placebo. Moderate study design 80 healthy women aged 25-40 with premenstrual symptoms (40 per group) ## What they did 80 healthy women aged 25-40 with premenstrual symptoms were randomly assigned to take tablets with either Lactobacillus paragasseri OLL2809 or placebo for 3 menstrual cycles. Researchers measured symptoms using questionnaires about menstrual distress. ## What they found The OLL2809 group had significantly greater improvements in premenstrual energy and activity compared to placebo. They also reported significantly lower premenstrual irritability than the placebo group. ## What it means for you This bacteria supplement might help improve mood and energy during the premenstrual phase. The study is small (40 women per group) and only tested healthy women, so results may not apply to those with severe PMDD. More research is needed. 80 Women enrolled 40 Women per group 3 Menstrual cycles ## About the study Original title Lactobacillus paragasseri OLL2809 Improves Premenstrual Psychological Symptoms in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Study Authors Sato A, Fukawa-Nagira A, Sashihara T Journal Nutrients Year 2023 Study design Randomised trial Participants 40 What was tested Lactobacillus paragasseri OLL2809 tablets versus placebo for 3 menstrual cycles Open access Yes Read the paper [doi.org/10.3390/nu15234985](https://doi.org/10.3390/nu15234985) Original abstract Lactobacillus paragasseri OLL2809 has been shown to ameliorate stress. This study employed a randomized, placebo-controlled, double-blind, parallel-group design to assess the efficacy of continuous ingestion of OLL2809 for managing menstrual symptoms in healthy women. Eighty healthy adult women aged 25-40 years who experienced premenstrual and menstrual symptoms were randomly assigned to either the OLL2809 or placebo group ( n = 40 each) and ingested tablets containing OLL2809 or placebo for three menstrual cycles. The OLL2809 group exhibited a significantly greater change in premenstrual 'arousal' scores on the menstrual distress questionnaire compared to the placebo group after the three menstrual cycles. Specifically, changes in the 'activity' subfactor were significantly higher in the OLL2809 group than in the placebo group. Additionally, the OLL2809 group reported significantly lower premenstrual irritability on the visual analog scale than the placebo group. These results suggest that OLL2809 may contribute to enhancing the quality of life of women. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Irritability and anger](https://niyora.com/research/topics/symptom-irritability-anger/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2026 Does a birth control pill with estetrol and drospirenone help PMS? Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? Survey study, 2026 How do pre-menstrual symptoms affect the work and social life of young women? Survey study, 2025 How does premenstrual syndrome change in women during wartime compared to peacetime? Survey study, 2020 Do women with IBS and period problems have worse psychological symptoms? Survey study, 2015 How common is PMS in Turkish medical students and does it affect quality of life? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗