---
title: Does lamotrigine help when antidepressants don't work well enough for severe PMDD?
description: One woman with severe PMDD significantly improved when lamotrigine was added to her antidepressant. This is one person's experience, so we can't be sure it wo
url: https://niyora.com/research/papers/lamotrigine-augmentation-in-premenstrual-dysphoric-disorder-a-case-report-2013/
---

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- Does lamotrigine help when antidepressants don't work well enough for severe PMDD?

Case report, 2013

# Does lamotrigine help when antidepressants don't work well enough for severe PMDD?

One woman with severe PMDD significantly improved when lamotrigine was added to her antidepressant. This is one person's experience, so we can't be sure it would work for everyone.

 Early or limited evidence

One 42-year-old woman with severe PMDD

## What they did

Doctors treated one 42-year-old woman with severe PMDD that wasn't controlled well enough with an antidepressant (SSRI) alone. They added lamotrigine, another mood medication.

## What they found

She significantly improved after the lamotrigine was added to her treatment.

## What it means for you

This is one woman's experience. It suggests lamotrigine might help when antidepressants don't work well enough for severe PMDD, but larger studies are needed to know for sure.

42 years old

age of patient

## About the study

Original title Lamotrigine augmentation in premenstrual dysphoric disorder: a case report Authors Sepede G, Martinotti G, Gambi F et al. Journal Clinical neuropharmacology Year 2013 Study design Case report What was tested Lamotrigine added to SSRI (antidepressant) treatment Read the paper [doi.org/10.1097/wnf.0b013e318279ee1f](https://doi.org/10.1097/wnf.0b013e318279ee1f)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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How do women respond differently to psychiatric medications and why do we need sex-specific treatments?

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