---
title: Are LHRH agonist drugs helpful for treating severe PMS? | Niyora
description: LHRH agonists appear beneficial for some women with severe premenstrual tension but worsen symptoms in others. They cause serious side effects like bone loss,
url: https://niyora.com/research/papers/lhrh-analogues-in-the-management-of-uterine-fibroids-premenstrual-syndrome-and-1988/
---

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- Are LHRH agonist drugs helpful for treating severe PMS?

Review, 1988

# Are LHRH agonist drugs helpful for treating severe PMS?

LHRH agonists appear beneficial for some women with severe premenstrual tension but worsen symptoms in others. They cause serious side effects like bone loss, making them unsuitable as long-term treatment for younger women.

 Early or limited evidence

Review article on LHRH agonists for various conditions including PMS

## What they did

Review of research on LHRH agonist drugs and their use in managing premenstrual syndrome, uterine fibroids, and breast cancer.

## What they found

LHRH agonists appear beneficial for managing some women with severe premenstrual tension but intensify symptoms in others. They work by suppressing ovarian function but cause adverse effects including loss of bone mass. Response depends on the degree of ovarian suppression.

## What it means for you

These drugs are not practical as routine PMS treatment for younger women because they cause significant bone loss and help some women while worsening symptoms in others. The review notes that PMS shows high placebo response rates, making it difficult to assess true drug effectiveness.

## About the study

Original title LHRH analogues in the management of uterine fibroids, premenstrual syndrome and breast malignancies Authors West CP Journal Bailliere's clinical obstetrics and gynaecology Year 1988 Study design Review What was tested LHRH agonist drugs Read the paper [doi.org/10.1016/s0950-3552(88)80053-1](https://doi.org/10.1016/s0950-3552(88)80053-1)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

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