--- title: Does connective tissue manipulation help dysmenorrhea pain and other symptoms? description: Yes, connective tissue manipulation reduced pain and fatigue significantly. Longer treatment appeared to have longer-lasting benefits through 12 months. url: https://niyora.com/research/papers/long-term-follow-up-result-of-connective-tissue-manipulation-in-young-women-with-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does connective tissue manipulation help dysmenorrhea pain and other symptoms? Survey study, 2023 # Does connective tissue manipulation help dysmenorrhea pain and other symptoms? Yes, connective tissue manipulation reduced pain and fatigue significantly. Longer treatment appeared to have longer-lasting benefits through 12 months. Early or limited evidence 35 women with dysmenorrhea (18 in group 1, 17 in group 2) ## What they did Two groups of women with dysmenorrhea received connective tissue manipulation. Group 1 (n=18) received it between 2 menstrual cycles and group 2 (n=17) received it between 3 menstrual cycles. Both groups were followed for 12 months. ## What they found Both groups had significant decreases in pain and fatigue after treatment and at 3-month and 6-month follow-up (p=0.001). Group 2 maintained improvement at 12-month follow-up (p=0.0001). No significant improvement in sleep quality. The two groups did not differ from each other. ## What it means for you Connective tissue manipulation may help dysmenorrhea pain and fatigue, possibly with longer-lasting effects from longer treatment. However, the sample is very small and there was no untreated control group for comparison. 35 Total women p=0.001 Pain and fatigue improvement at 6 months 12 Months of follow-up ## About the study Original title Long-Term Follow-Up Result of Connective Tissue Manipulation in Young Women with Primary Dysmenorrhea: Different Intervention Durations Authors Yagci N, Senel A, Atalay OT et al. Journal Reproductive sciences (Thousand Oaks, Calif.) Year 2023 Study design Survey study Participants 18 What was tested Connective tissue manipulation applied between menstrual cycles Read the paper [doi.org/10.1007/s43032-023-01172-5](https://doi.org/10.1007/s43032-023-01172-5) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Fatigue and energy](https://niyora.com/research/topics/symptom-fatigue/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2025 Do menstrual problems and poor sleep affect mood and thinking in teenage girls? Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Survey study, 2026 Are menstrual characteristics linked to depression and anxiety in teenage girls? Survey study, 2019 What lifestyle and sleep habits are linked to PMS in teenage girls? Randomised trial, 2018 Does swimming reduce premenstrual syndrome symptoms? Survey study, 2017 Does painful menstruation affect adolescent girls' mood, emotions, sleep, and thinking? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗