--- title: Does depression that worsens before the period differ from other depression? description: No major differences in depression type or treatment response, but women with premenstrual worsening had more seasonal mood patterns and different personality url: https://niyora.com/research/papers/longitudinal-study-comparing-depressive-female-patients-with-and-without-2010/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does depression that worsens before the period differ from other depression? Cohort study, 2010 # Does depression that worsens before the period differ from other depression? No major differences in depression type or treatment response, but women with premenstrual worsening had more seasonal mood patterns and different personality traits (more self-control). Moderate study design 74 women who achieved remission from major depression after 16 weeks of treatment (from initial 99 outpatients) ## What they did Longitudinal cohort study. 99 outpatients with major depression (not taking medication at baseline) were interviewed. After 16 weeks of treatment, 74 patients achieved remission (depression rating score of 7 or less). These 74 women then completed personality and cognitive tests. ## What they found No differences were found between women with and without premenstrual exacerbation of depression in depression type or how well treatment worked, except women with premenstrual exacerbation were more likely to have seasonal features. Women with premenstrual exacerbation scored higher on self-control personality trait and lower on a cognitive test (D48/Dominos test). Higher self-control scores increased the risk for premenstrual exacerbation by 51.3%, while higher cognitive test scores decreased the risk by 8.6%. ## What it means for you Women whose depression gets worse before their period do not have a fundamentally different type of depression or response to treatment. They may have different personality patterns (more self-control) and cognitive patterns. This study was limited to women whose depression responded well to treatment, so findings may not apply to all women. 74 Women who achieved remission 51.3% Increased risk for PE with higher self-control 8.6% Decreased risk for PE with higher cognitive scores ## About the study Original title [Longitudinal study comparing depressive female patients with and without premenstrual exacerbation] Authors Benavente Martín JL, Olivares Diez JM, Calado Otero M et al. Journal Revista de psiquiatria y salud mental Year 2010 Study design Cohort study Participants 74 What was tested Standard depression treatment (specific medications not detailed) Read the paper [doi.org/10.1016/j.rpsm.2010.05.001](https://doi.org/10.1016/j.rpsm.2010.05.001) ## Topics [Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2000 How should PMDD be diagnosed and treated? Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Randomised trial, 2013 Do women with depression whose symptoms worsen before their period respond differently to antidepressants? Survey study, 2011 How common is PMDD in women with depression compared to healthy women? Randomised trial, 2008 Does taking more antidepressant just before the period help depression that worsens then? Study, 2005 Do women with depression experience worsening of symptoms before their period? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗