---
title: Does rofecoxib reduce premenstrual acne? | Niyora
description: Yes. Rofecoxib was more effective than placebo at reducing premenstrual acne.
url: https://niyora.com/research/papers/management-of-premenstrual-acne-with-cox-2-inhibitors-a-placebo-controlled-study-2004/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does rofecoxib reduce premenstrual acne?

Randomised trial, 2004

# Does rofecoxib reduce premenstrual acne?

Yes. Rofecoxib was more effective than placebo at reducing premenstrual acne.

 Early or limited evidence

80 women with premenstrual acne

## What they did

A placebo-controlled trial where 80 women with premenstrual acne were given either rofecoxib or placebo for 10 days for two menstrual cycles. Acne severity was measured using an acne severity index and by counting inflammatory acne lesions.

## What they found

Rofecoxib was more effective than placebo. The abstract notes results suggest rofecoxib is effective in managing premenstrual acne and that prostaglandin PGE2 may be involved in its pathogenesis, but specific numerical results were not provided.

## What it means for you

Rofecoxib may help reduce premenstrual acne by reducing inflammation. However, the study was small (80 women) and lacked detailed results in the abstract, so more research is needed. The findings were from India.

80

women in study

10 days

treatment duration per cycle

2 cycles

study duration

## About the study

Original title Management of premenstrual acne with Cox-2 inhibitors: a placebo controlled study Authors Tehrani R, Dharmalingam M Journal Indian journal of dermatology, venereology and leprology Year 2004 Study design Randomised trial What was tested Rofecoxib (Cox-2 inhibitor) or placebo for 10 days per cycle, two cycles Read the paper [https://pubmed.ncbi.nlm.nih.gov/17642660/](https://pubmed.ncbi.nlm.nih.gov/17642660/)

## Topics

[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗