---
title: Do women with PMS have different hormone levels during their menstrual cycle?
description: Overall, hormone levels are similar in women with and without PMS, but the peak of progesterone happens later in women with PMS.
url: https://niyora.com/research/papers/menstrual-cycle-hormonal-profiles-of-women-with-and-without-premenstrual-1993/
---

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- Do women with PMS have different hormone levels during their menstrual cycle?

Study, 1993

# Do women with PMS have different hormone levels during their menstrual cycle?

Overall, hormone levels are similar in women with and without PMS, but the peak of progesterone happens later in women with PMS.

 Moderate study design

65 women with documented PMS and 18 women without PMS

## What they did

65 women with PMS and 18 women without PMS collected all their urine every day for one complete menstrual cycle. Researchers measured the hormones estrogen and pregnanediol (a breakdown product of progesterone) in the urine.

## What they found

Hormone levels overall were similar between the two groups. However, the peak of pregnanediol happened later in women with PMS compared to women without PMS. The menstrual cycle was also shorter for women without PMS.

## What it means for you

There was no evidence that women with PMS have low progesterone levels. However, the delayed timing of the progesterone peak might be important. The study only measured one cycle, and the control group was small, so more research is needed.

65

Women with PMS

18

Women without PMS

## About the study

Original title Menstrual cycle hormonal profiles of women with and without premenstrual syndrome Authors Dennerstein L, Brown JB, Gotts G et al. Journal Journal of psychosomatic obstetrics and gynaecology Year 1993 Study design Study Participants 65 What was tested None - observational Read the paper [doi.org/10.3109/01674829309084449](https://doi.org/10.3109/01674829309084449)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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