--- title: Do menstrual cycle hormones cause premenstrual syndrome, and can stopping ovulation help? description: Stopping ovulation significantly reduced physical and mood symptoms, suggesting hormones are involved. However, some women still had symptom flare-ups even wh url: https://niyora.com/research/papers/modification-of-symptoms-of-the-premenstrual-syndrome-during-ovarian-suppression-1989/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do menstrual cycle hormones cause premenstrual syndrome, and can stopping ovulation help? Study, 1989 # Do menstrual cycle hormones cause premenstrual syndrome, and can stopping ovulation help? Stopping ovulation significantly reduced physical and mood symptoms, suggesting hormones are involved. However, some women still had symptom flare-ups even when hormone levels showed no ovulation, showing the link between hormones and symptoms is more complex than expected. Early or limited evidence 11 women with premenstrual problems ## What they did 11 women with premenstrual problems received monthly injections of goserelin 3.6mg under the skin for up to 6 months. Doctors measured hormone levels twice weekly and women tracked their symptoms daily. ## What they found Physical and psychological symptoms improved significantly during treatment. However, some women still reported swelling and mood changes even though their hormone levels showed they were not ovulating. Three women reported anxiety and/or depression got worse soon after starting treatment (one withdrew from the study). When ovulation returned after treatment ended, symptoms came back to their original levels, though breast discomfort stayed improved. ## What it means for you These results suggest menstrual cycle hormones do affect mood and physical symptoms, but the connection is not simple. Stopping ovulation did not eliminate all symptoms for everyone. The study is limited because it only included 11 women and had no comparison group to measure against. 11 women treated 6 maximum months of treatment 3 women who reported worsened mood symptoms ## About the study Original title Modification of symptoms of the premenstrual syndrome during ovarian suppression with goserelin (Zoladex) depot – potential for research and clinical investigation Authors Christine P. West, Mary Ann Lumsden, David T. Baird Journal Journal of Psychosomatic Obstetrics & Gynecology Year 1989 Study design Study What was tested Goserelin 3.6mg monthly injections Read the paper [doi.org/10.3109/01674828909016680](https://doi.org/10.3109/01674828909016680) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 What are the best treatments for PMDD and PMS? Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Systematic review, 2022 What are the best treatments for PMDD and PMS? Review, 2015 What do we know about PMS and PMDD and how are they treated? Review, 2008 What medications are FDA-approved for treating PMDD? Study, 2026 What treatments work for PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗