---
title: Does myo-inositol help reduce PMDD symptoms? | Niyora
description: No, myo-inositol (12 g daily) did not reduce PMDD symptoms more than placebo.
url: https://niyora.com/research/papers/myo-inositol-has-no-beneficial-effect-on-premenstrual-dysphoric-disorder-2002/
---

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- Does myo-inositol help reduce PMDD symptoms?

Randomised trial, 2002

# Does myo-inositol help reduce PMDD symptoms?

No, myo-inositol (12 g daily) did not reduce PMDD symptoms more than placebo.

 Moderate study design

11 women with PMDD

## What they did

Eleven women with PMDD took either myo-inositol (12 g daily) or glucose placebo during the luteal phase only, 14 days before menses. The study was a crossover, double-blind, placebo-controlled trial lasting 6 menstrual cycles, with treatment alternating each cycle.

## What they found

No beneficial effect was demonstrated for inositol over placebo.

## What it means for you

Although myo-inositol has helped with depression, panic, and other conditions in previous research, it does not appear to help PMDD. The sample was small (11 women), so results should be confirmed in larger studies.

11

Number of women

12 g

Daily dose

14 days

Duration of treatment before menses

## About the study

Original title Myo-inositol has no beneficial effect on premenstrual dysphoric disorder Authors Nemets B, Talesnick B, Belmaker RH et al. Journal The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Year 2002 Study design Randomised trial What was tested Myo-inositol 12 g daily Read the paper [doi.org/10.3109/15622970209150615](https://doi.org/10.3109/15622970209150615)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Anxiety disorders and OCD](https://niyora.com/research/topics/comorbidity-anxiety-disorders/)[Eating disorders](https://niyora.com/research/topics/comorbidity-eating-disorders/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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