---
title: Do women with PMS have different hormone pulse patterns than women without symptoms?
description: Yes. Women with PMS had more frequent but smaller pulses of progesterone and LH during the luteal phase compared to women without symptoms, even though overal
url: https://niyora.com/research/papers/neuroendocrine-changes-in-luteal-function-in-patients-with-premenstrual-syndrome-1993/
---

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- Do women with PMS have different hormone pulse patterns than women without symptoms?

Survey study, 1993

# Do women with PMS have different hormone pulse patterns than women without symptoms?

Yes. Women with PMS had more frequent but smaller pulses of progesterone and LH during the luteal phase compared to women without symptoms, even though overall hormone levels were similar.

 Early or limited evidence

14 women with confirmed PMS and 14 women without symptoms

## What they did

Cross-sectional study of 14 women with confirmed PMS and 14 women without symptoms. Blood samples were drawn every 10 minutes for 12 hours during the luteal phase. Progesterone and LH pulses were measured and compared.

## What they found

Women with PMS had higher progesterone pulse frequency (13.4 ± 1.8 vs 11.4 ± 2.3, P < 0.02) and reduced pulse amplitude (126.5 ± 61.6% vs 187.1 ± 126.7%, P < 0.03). Mean 12-hour progesterone and LH levels were similar. Progesterone pulses followed LH pulses with a 0-10 minute delay in both groups.

## What it means for you

The authors conclude PMS involves altered hormone release patterns despite normal overall levels, suggesting a neuroendocrine disorder. The main limitation is the small sample size of 14 per group, and findings only apply to the luteal phase.

13.4 vs 11.4

Progesterone pulse frequency, PMS vs controls

126.5 vs 187.1

Pulse amplitude (%), PMS vs controls

14

Women in each group

## About the study

Original title Neuroendocrine changes in luteal function in patients with premenstrual syndrome Authors Facchinetti F, Genazzani AD, Martignoni E et al. Journal The Journal of clinical endocrinology and metabolism Year 1993 Study design Survey study Participants 14 What was tested None Read the paper [doi.org/10.1210/jcem.76.5.8496301](https://doi.org/10.1210/jcem.76.5.8496301)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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