---
title: Is neurotensin involved in causing PMS? | Niyora
description: No. Women with PMS had similar neurotensin levels in their spinal fluid compared to healthy women. This brain chemical does not appear to be abnormal in PMS.
url: https://niyora.com/research/papers/neurotensin-like-immunoreactivity-in-cerebrospinal-fluid-of-patients-with-1989/
---

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- Is neurotensin involved in causing PMS?

Study, 1989

# Is neurotensin involved in causing PMS?

No. Women with PMS had similar neurotensin levels in their spinal fluid compared to healthy women. This brain chemical does not appear to be abnormal in PMS.

 Early or limited evidence

Patients with PMS and healthy control women

## What they did

Researchers measured neurotensin (a brain chemical) in the spinal fluid of patients with various psychiatric conditions including PMS, and compared them to healthy controls.

## What they found

Neurotensin levels were the same in people with PMS as in the control group. Levels were not changed and did not show any pattern related to PMS.

## What it means for you

This brain chemical does not appear to be abnormal in PMS, so it is probably not involved in causing PMS. However, this is only one chemical in the brain, so finding that it is normal does not tell us what does cause PMS. The number of PMS participants is not clearly stated, which is a limitation.

## About the study

Original title Neurotensin-like immunoreactivity in cerebrospinal fluid of patients with schizophrenia, depression, anorexia nervosa-bulimia, and premenstrual syndrome Authors Nemeroff CB, Bissette G, Widerlov E et al. Journal The Journal of neuropsychiatry and clinical neurosciences Year 1989 Study design Study What was tested None - laboratory measurement study Read the paper [doi.org/10.1176/jnp.1.1.16](https://doi.org/10.1176/jnp.1.1.16)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Eating disorders](https://niyora.com/research/topics/comorbidity-eating-disorders/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/)

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