---
title: Does indoprofen help premenstrual migraine? | Niyora
description: In this very small study, indoprofen appeared to reduce pain levels and decrease a prostaglandin marker in fluid from around the brain.
url: https://niyora.com/research/papers/new-contributions-on-extinction-tests-of-essential-headache-ii-the-test-with-1983/
---

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- Does indoprofen help premenstrual migraine?

Study, 1983

# Does indoprofen help premenstrual migraine?

In this very small study, indoprofen appeared to reduce pain levels and decrease a prostaglandin marker in fluid from around the brain.

 Early or limited evidence

3 women with premenstrual migraine

## What they did

They gave 3 women with premenstrual migraine an intravenous dose of indoprofen 400 mg. They measured levels of a prostaglandin (PGF2 alpha) in cerebrospinal fluid (the fluid around the brain and spinal cord) at 0, 15, 30, and 45 minutes after injection. They also measured pain using a visual pain scale.

## What they found

The treatment decreased levels of PGF2 alpha in the cerebrospinal fluid and decreased pain levels on the visual pain scale.

## What it means for you

Indoprofen may help premenstrual migraine by reducing prostaglandins. However, this was only 3 women with no comparison group, so much larger studies are needed to know if this treatment really works.

3

Women with premenstrual migraine studied

400 mg

Indoprofen dose given intravenously

## About the study

Original title [New contributions on extinction tests of essential headache. II. The test with indoprofen] Authors Martelletti P, Romiti A, Gallo MF et al. Journal Bollettino della Societa italiana di biologia sperimentale Year 1983 Study design Study What was tested Indoprofen 400 mg given into a vein Read the paper [https://pubmed.ncbi.nlm.nih.gov/6578800/](https://pubmed.ncbi.nlm.nih.gov/6578800/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)

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