---
title: Can SSRI antidepressants treat premenstrual syndrome? | Niyora
description: Yes, SSRIs are particularly effective for treating premenstrual syndrome symptoms.
url: https://niyora.com/research/papers/new-indications-for-antidepressive-agents-now-also-in-anxiety-disorders-and-2000/
---

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- Can SSRI antidepressants treat premenstrual syndrome?

Review, 2000

# Can SSRI antidepressants treat premenstrual syndrome?

Yes, SSRIs are particularly effective for treating premenstrual syndrome symptoms.

 Early or limited evidence

Women with premenstrual syndrome

## What they did

This is a brief review section discussing SSRI use for premenstrual syndrome among other conditions.

## What they found

SSRIs and other medications like nefazodone and venlafaxine can effectively treat premenstrual syndrome.

## What it means for you

For women with PMS, SSRI antidepressants are a treatment option. The main limit is that this was just a brief mention in a broader review, not detailed research specifically about PMS.

## About the study

Original title [New indications for antidepressive agents. Now also in anxiety disorders and premenstrual syndrome?] Authors Hochstrasser B Journal MMW Fortschritte der Medizin Year 2000 Study design Review What was tested SSRI antidepressants Read the paper [https://pubmed.ncbi.nlm.nih.gov/11190938/](https://pubmed.ncbi.nlm.nih.gov/11190938/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Stress](https://niyora.com/research/topics/symptom-stress/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Anxiety disorders and OCD](https://niyora.com/research/topics/comorbidity-anxiety-disorders/)[PTSD and trauma](https://niyora.com/research/topics/comorbidity-ptsd-trauma/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2000

What conditions beyond depression can antidepressants treat?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Review, 1999

Is premenstrual dysphoric disorder a distinct clinical disorder?

Lab study, 2020

Does anxiety sensitivity change during different parts of the menstrual cycle?

Cohort study, 2012

How quickly does fluoxetine start working for PMDD symptoms?

Randomised trial, 2004

Does paroxetine controlled-release help PMDD symptoms?

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