---
title: Does vitamin B-6 help premenstrual tension? | Niyora
description: No. Vitamin B-6 at 100 mg daily was no better than placebo for relieving premenstrual tension.
url: https://niyora.com/research/papers/no-effect-of-vitamin-b-6-against-premenstrual-tension-a-controlled-clinical-1985/
---

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- Does vitamin B-6 help premenstrual tension?

Randomised trial, 1985

# Does vitamin B-6 help premenstrual tension?

No. Vitamin B-6 at 100 mg daily was no better than placebo for relieving premenstrual tension.

 Moderate study design

34 women with premenstrual tension

## What they did

A randomized double-blind crossover trial where 34 women with premenstrual tension received either vitamin B-6 (100 mg daily) or placebo. The researchers also measured blood magnesium in these women and in 10 healthy women without premenstrual tension.

## What they found

Vitamin B-6 was no better than placebo at relieving premenstrual tension. Women preferred whichever pill they received second, regardless of what it was. Blood magnesium levels were not significantly different between women with premenstrual tension and healthy women. Vitamin B-6 did cause a small but statistically significant rise in blood magnesium level, but this change did not correlate with symptom improvement in individual women.

## What it means for you

Vitamin B-6 doesn't appear to help premenstrual tension. The study was small (34 women) and from 1985. Women preferred whichever treatment they received second, suggesting expectation effects may have influenced results.

100 mg

Daily dose of vitamin B-6

34

Women with premenstrual tension

10

Healthy women without premenstrual tension

## About the study

Original title No effect of vitamin B-6 against premenstrual tension. A controlled clinical study Authors Hagen I, Nesheim BI, Tuntland T Journal Acta obstetricia et gynecologica Scandinavica Year 1985 Study design Randomised trial Participants 34 What was tested Vitamin B-6 100 mg daily throughout the menstrual cycle Read the paper [doi.org/10.3109/00016348509158211](https://doi.org/10.3109/00016348509158211)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)

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