--- title: Does Mabelle Cycle help restore regular periods in women with stress-related problems? description: Yes, more women taking Mabelle Cycle restored regular periods compared to those in the control group. After three months, 62.5% of those taking Mabelle Cycle url: https://niyora.com/research/papers/nonhormonal-adjustment-of-stress-associated-menstrual-cycle-disorders-data-of-2025/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does Mabelle Cycle help restore regular periods in women with stress-related problems? Non-randomised trial, 2025 # Does Mabelle Cycle help restore regular periods in women with stress-related problems? Yes, more women taking Mabelle Cycle restored regular periods compared to those in the control group. After three months, 62.5% of those taking Mabelle Cycle had restored cycles versus 27.5% in the control group. Moderate study design 80 women aged 18-31 (mean age 24.4 years) with stress-related menstrual disorders ## What they did Researchers divided 80 women aged 18-31 with stress-related period problems into two groups for 3 months. One group (n=40) took Mabelle Cycle supplement. The other (n=40) received psychology consultation and physiotherapy. ## What they found Mabelle Cycle group showed progressive improvement: 22.5% restored cycles after month 1, 50% after month 2, and 62.5% after month 3. The control group showed 7.5%, 17.5%, and 27.5% respectively. Differences were statistically significant from month 2 (p=0.008). The Mabelle Cycle group also showed mood swings reduced from 45% to 7.5%, breast pain reduced from 40% to 10%, and depressive symptoms completely resolved. ## What it means for you A herbal supplement may help restore periods and reduce PMS symptoms in women stressed about their cycles. The study was not randomized and was open-label (participants knew what they were taking), so there may be bias. Results cannot be directly applied to all women with period problems. 62.5% Mabelle group with restored cycles at month 3 27.5% Control group with restored cycles at month 3 45% to 7.5% Mood swings reduction in Mabelle group ## About the study Original title Nonhormonal adjustment of stress-associated menstrual cycle disorders: data of MONARCH trial on the use of Mabelle Cycle complex Authors Viktor E. Radzinskiy, Mekan R Orazov, Marina Borisovna Khamoshina et al. Journal Clinical review for general practice Year 2025 Study design Non-randomised trial Participants 40 What was tested Mabelle Cycle supplement (2 tablets daily for 3 months) versus psychology consultation and physiotherapy Open access Yes Read the paper [doi.org/10.47407/kr2025.6.8.00663](https://doi.org/10.47407/kr2025.6.8.00663) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2025 Which is more effective for PMS - Vitagnus, soy, or both together? Randomised trial, 2023 Can herbal medicine prevent or treat PMS and menstrual disorders? Randomised trial, 2022 Do herbal medicines and nutritional supplements help relieve PMS symptoms? Systematic review, 2017 Does Vitex agnus castus help treat premenstrual syndrome? Systematic review, 2017 Is Vitex agnus castus safe and effective for treating PMS and PMDD? Review, 2015 What do we know about PMS and PMDD and how are they treated? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗