---
title: Does the uterine lining cause premenstrual syndrome? | Niyora
description: Possibly. Women with PMS who had surgery to remove their uterine lining improved when their periods stopped, and symptoms returned when periods came back.
url: https://niyora.com/research/papers/origin-of-premenstrual-syndrome-assessment-by-endometrial-ablation-1994/
---

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- Does the uterine lining cause premenstrual syndrome?

Non-randomised trial, 1994

# Does the uterine lining cause premenstrual syndrome?

Possibly. Women with PMS who had surgery to remove their uterine lining improved when their periods stopped, and symptoms returned when periods came back.

 Early or limited evidence

108 women having endometrial ablation for heavy bleeding; 73 had PMS

## What they did

Observational study of 108 women having endometrial ablation (surgery to remove the uterine lining) for heavy menstrual bleeding. Of these women, 73 also had PMS. Researchers assessed their symptoms before surgery and 1 to 2 years after surgery.

## What they found

After surgery most women initially had no periods and their PMS improved significantly. When menstrual bleeding returned in some women, PMS often recurred. Women who remained amenorrheic remained free of PMS symptoms.

## What it means for you

The findings suggest that substances from the uterine lining may contribute to PMS. The main limits are that this was only studied in women with heavy bleeding (not all PMS women), there was no control group, and surgery is not a practical or standard treatment for PMS.

108

women having surgery

73

with PMS

1-2

years of follow-up

## About the study

Original title Origin of premenstrual syndrome: assessment by endometrial ablation Authors Lefler HT Jr, Lefler CF Journal The Journal of the American Association of Gynecologic Laparoscopists Year 1994 Study design Non-randomised trial Participants 108 What was tested Endometrial ablation with rollerbar resectoscope Read the paper [doi.org/10.1016/s1074-3804(05)81011-4](https://doi.org/10.1016/s1074-3804(05)81011-4)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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