--- title: Does premenstrual dysphoric disorder affect the heart's electrical patterns? description: Women with PMDD had higher P wave dispersion measurements than healthy women. The study is small, so we cannot be certain how important this is for real life. url: https://niyora.com/research/papers/p-wave-dispersion-in-patients-with-premenstrual-dysphoric-disorder-2019/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does premenstrual dysphoric disorder affect the heart's electrical patterns? Case-control study, 2019 # Does premenstrual dysphoric disorder affect the heart's electrical patterns? Women with PMDD had higher P wave dispersion measurements than healthy women. The study is small, so we cannot be certain how important this is for real life. Early or limited evidence 25 women with premenstrual dysphoric disorder and 25 healthy women ## What they did Researchers compared 25 women with PMDD to 25 healthy women. They measured each woman's heart electrical activity using an ECG machine. ## What they found Women with PMDD had significantly higher P wave dispersion values, and also higher Pmax and Pmin measurements, compared to healthy women. ## What it means for you Women with PMDD may have changes in their heart's electrical signals similar to what happens with anxiety. This could suggest a trend toward heart rhythm problems. The study was very small and larger studies are needed to know if this matters in real life. 25 women with PMDD 25 healthy control women Much higher P wave dispersion in PMDD ## About the study Original title P wave dispersion in patients with premenstrual dysphoric disorder Authors Şeyda Yavuzkır, Suna Aydın, Melike Mercan Başpınar et al. Journal Journal of Cardiology and Cardiovascular Medicine Year 2019 Study design Case-control study Open access Yes Read the paper [doi.org/10.29328/journal.jccm.1001046](https://doi.org/10.29328/journal.jccm.1001046) Original abstract Background: Growing evidence has revealed that fear and anxiety related situations could affect cardiac parameters. P wave dispersion (Pd) is an important index. In the present study, we aimed to evaluate Pd values in patients with premenstrual dysphoric disorder. Methods: The study was composed of twenty-five female patients with premenstrual dysphoric disorder and same number of healthy controls. Pd, Pmin and Pmax values were determined by electrocardiogram (ECG) in the subjects. Results: It was found that patients with premenstrual dysphoric disorder had considerably higher Pmax and Pmin values compared to those of healthy subjects. Pd was also significantly higher in patients with premenstrual dysphoric disorders than that of healthy subjects. Conclusion: Study suggests that patients with premenstrual dysphoric disorder seems to have increased Pd, as can be seen in anxiety and fear related clinical conditions, considering that this group of patients have an increased trend to cardiac abnormalities, particularly cardiac arrythmias. To access strong conclusion, it is required novel studies with larger samples. Reproduced under CC-BY. ## Topics [Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2026 Does vitamin D supplementation help PMS symptoms? Cohort study, 2025 Do women with PMS or PMDD report lower quality of life than women without these conditions? Non-randomised trial, 2008 Can the Sheehan Disability Scale measure whether treatments work? Systematic review, 2008 What treatments work best for PMS and PMDD? Review, 2003 How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD? Randomised trial, 2003 Are SSRI antidepressants effective for PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗