---
title: Does paroxetine treat premenstrual dysphoric disorder? | Niyora
description: Yes. Paroxetine is an antidepressant medication approved by the FDA and Health Canada for treating PMDD.
url: https://niyora.com/research/papers/paroxetine-use-in-the-treatment-of-premenstrual-dysphoric-disorder-2006/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does paroxetine treat premenstrual dysphoric disorder?

Study, 2006

# Does paroxetine treat premenstrual dysphoric disorder?

Yes. Paroxetine is an antidepressant medication approved by the FDA and Health Canada for treating PMDD.

 Moderate study design

Review article (describes PMDD in women of reproductive age).

## What they did

Reviewed information about paroxetine and how it fits into treatment guidelines for PMDD, including its approval status.

## What they found

PMDD affects 3-8% of women of reproductive age. Symptoms include depressed mood, irritability, anxiety, and physical symptoms that appear during the luteal phase (after ovulation) and go away within 3 days of the period starting. Treatment guidelines recommend lifestyle changes first, then medications. Paroxetine is an antidepressant and was recently approved by the US FDA and Health Canada specifically for PMDD.

## What it means for you

If lifestyle changes alone don't relieve your PMDD, paroxetine is an FDA-approved medication option that's recommended as a first-line treatment. This is a review of information, not evidence from a treatment trial.

3-8%

women with PMDD

## About the study

Original title Paroxetine use in the treatment of premenstrual dysphoric disorder Authors Misri S, Kendrick K Journal Women's health (London, England) Year 2006 Study design Study What was tested paroxetine for treating PMDD Open access Yes Read the paper [doi.org/10.2217/17455057.2.1.43](https://doi.org/10.2217/17455057.2.1.43)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

Does continuous paroxetine or birth control work better for PMDD?

Systematic review, 2026

Are there differences in brain activity in women with PMDD?

Study, 2026

Are SSRIs the first treatment doctors recommend for PMDD?

Randomised trial, 2025

Does taking an antidepressant only during the second half of your cycle reduce anger and aggression in PMDD?

Systematic review, 2024

What are the best treatments for PMDD and PMS?

Review, 2024

What are the most effective treatments for PMDD?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗