--- title: What menstrual and weight issues occur in women with Fragile X syndrome? description: This case describes one woman with Fragile X syndrome who experienced recurring menstrual cycle disorders, genital inflammation, and weight fluctuations. She url: https://niyora.com/research/papers/patient-with-martin-bell-syndrome-and-premenstrual-syndrome-tendency-for-obesity-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - What menstrual and weight issues occur in women with Fragile X syndrome? Study, 2022 # What menstrual and weight issues occur in women with Fragile X syndrome? This case describes one woman with Fragile X syndrome who experienced recurring menstrual cycle disorders, genital inflammation, and weight fluctuations. She required ongoing specialized care. Early or limited evidence One woman with Fragile X syndrome in Poland ## What they did This is a case report of one patient with Fragile X syndrome treated at a hospital in Poland. The patient had a family history of intellectual disability and weight fluctuations since childhood. ## What they found The patient had recurrent menstrual cycle disorders and genital inflammation. She required continuous gynecological, psychiatric, and dietary care. Physical activity was recommended, and these interventions had a beneficial effect on her physical and mental health. ## What it means for you Women with Fragile X syndrome may experience menstrual disorders, weight management challenges, and mental health concerns requiring specialized care. The main limitation is that this describes only one patient, so findings may not apply broadly. 1 patient in this case report ## About the study Original title Patient with Martin-Bell syndrome and premenstrual syndrome, tendency for obesity from puberty Authors Grażyna Jarząbek‐Bielecka, Małgorzata Mizgier, Katarzyna Plagens-Rotman et al. Journal Clinical and Experimental Obstetrics & Gynecology Year 2022 Study design Study What was tested Gynecological care, psychiatric care, diet therapy, and physical activity Open access Yes Read the paper [doi.org/10.31083/j.ceog4903073](https://doi.org/10.31083/j.ceog4903073) Original abstract Background: Fragile X syndrome (FRA X) is the most common cause of inherited moderate intellectual disability. The cause of FRA X syndrome is a dynamic mutation in the FMR1 gene (located on the X sex chromosome—long arm, position 27.3, between base pairs 147 911 951 and 147 951 125). Case(s): A patient born in 1993 along with her mother was referred to the Department of Developmental Age Gynaecology and Gynaecological Sexology of the Obstetrical Clinical Hospital at the Poznań University of Medical Sciences (Poland) because of existing recurrent menstrual cycle disorders and recurrent genital inflammation. From her history since childhood, this patient had fluctuating body weight with a tendency for overweight and obesity. Contact with the patient was difficult, she was reluctant to answer questions during the medical interview. There is a family history of intellectual disability. The patient required continuous gynaecological and psychiatric care, diet therapy, physical activity was recommended, which had a beneficial effect on the patient’s somatic and mental health. Conclusions: The diagnosis of fragile X syndrome involved not only the patient but also her family in a very broad interdisciplinary approach, also in terms of genetic counselling. Additional problems with cycle disorders, genital inflammation and weight disorders mean that the patient will still require gynaecological and psychiatric care, diet therapy, and physical activity has been recommended, which has a beneficial effect on the patient’s somatic and mental health. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Psychotherapy, counselling and education](https://niyora.com/research/topics/treatment-psychotherapy/)[Exercise and yoga](https://niyora.com/research/topics/treatment-exercise/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2025 Can adolescent girls manage PMS without medication? Non-randomised trial, 2026 Does a lifestyle education program reduce PMS symptoms? Randomised trial, 2025 Does aerobic exercise with lifestyle changes reduce PMS symptoms in college students? Survey study, 2019 What causes severe PMS in female college students with disabilities? Survey study, 2026 How common is PMS in Yemen and what lifestyle factors affect it? Survey study, 2026 How do pre-menstrual symptoms affect the work and social life of young women? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗