---
title: Are physical PMS symptoms linked to progesterone and other hormones?
description: Symptoms peaked 1-3 days before menstruation, delayed 3-6 days after hormone peaks. Progesterone was more linked to symptoms than desoxycorticosterone.
url: https://niyora.com/research/papers/physical-symptoms-in-premenstrual-syndrome-are-related-to-plasma-progesterone-2000/
---

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- Are physical PMS symptoms linked to progesterone and other hormones?

Study, 2000

# Are physical PMS symptoms linked to progesterone and other hormones?

Symptoms peaked 1-3 days before menstruation, delayed 3-6 days after hormone peaks. Progesterone was more linked to symptoms than desoxycorticosterone.

 Early or limited evidence

10 women with PMS and 8 control women

## What they did

Ten women with PMS (with swelling as main symptom) and eight control women tracked three physical symptoms every evening for one menstrual cycle while researchers measured progesterone and desoxycorticosterone in blood samples.

## What they found

Physical symptoms reached their peak 1-3 days before menstruation, with a lag of 3-6 days after the hormone peak. Women with PMS and control women had the same desoxycorticosterone levels. Progesterone was more strongly linked to symptoms than desoxycorticosterone.

## What it means for you

Progesterone appears more important than desoxycorticosterone for physical PMS symptoms. The study was very small, measured only one cycle in each woman, focused on one symptom type (swelling), and may not apply to other symptoms or all women with PMS.

10

women with PMS

8

control women

1-3

days before menstruation when symptoms peaked

## About the study

Original title Physical symptoms in premenstrual syndrome are related to plasma progesterone and desoxycorticosterone Authors Seippel L, Eriksson O, Grankvist K et al. Journal Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Year 2000 Study design Study What was tested None Read the paper [doi.org/10.3109/09513590009167679](https://doi.org/10.3109/09513590009167679)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)[Economic burden](https://niyora.com/research/topics/life-area-economic-burden/)

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## Related studies

Review, 2003

How do menstrual cycle hormones affect the brain and cause mood disorders like PMDD?

Review, 2010

Can neurosteroids help with anxiety and brain disorders?

Review, 2006

How do brain hormones affect PMDD and mood problems during the menstrual cycle?

Review, 2003

What role do hormones play in PMS and how should we treat it?

Review, 2002

What treatments work for PMDD?

Randomised trial, 2001

Do women with PMS have different brain receptors that change with hormones?

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