--- title: Does Tazalok work better than Vitex for treating PMS? | Niyora description: After 3 months, Tazalok improved hormone levels more than Vitex, with bigger improvements in depression and pain. Since women were not randomly assigned to gr url: https://niyora.com/research/papers/phytoselective-therapy-is-a-method-of-choice-for-the-treatment-of-mastopathy-in-2020/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does Tazalok work better than Vitex for treating PMS? Study, 2020 # Does Tazalok work better than Vitex for treating PMS? After 3 months, Tazalok improved hormone levels more than Vitex, with bigger improvements in depression and pain. Since women were not randomly assigned to groups, we cannot be completely certain about these differences. Moderate study design 120 women aged 22 to 39 with PMS and breast hormone diseases ## What they did 120 women aged 22 to 39 with PMS were divided into two groups of 60 each. One group took Tazalok for 3 months, the other took Vitex derivative for 3 months. Hormone levels, thyroid function, depression, and pain were measured at 1 month and 3 months. Ultrasound images were also taken. ## What they found At 1 month, Tazalok group had better hormone levels and fewer complaints, while Vitex group mainly had reduced prolactin. At 3 months, Tazalok group had all hormone levels return to normal including cortisol and thyroid hormones, depression scores dropped a lot, pain scores dropped a lot, and blood vessels in breast, thyroid, and pelvic organs improved. Vitex group had cortisol and thyroid hormones that stayed abnormal, progesterone and luteinizing hormone were lower than the Tazalok group, had abnormal blood vessels in thyroid and uterus, depression went down slightly, and pain went down but less than in the Tazalok group. ## What it means for you Tazalok appears to work better for improving hormones and mood than Vitex. Main limitation: women were not randomly assigned to treatment groups, so this is not a randomized trial. 120 women studied 60 women in each group 3 months treatment duration ## About the study Original title Phytoselective therapy is a method of choice for the treatment of mastopathy in combination with premenstrual syndrome Authors O. V. Gryshchenko, В. В. Бобрицкая Journal Reproductive Endocrinology Year 2020 Study design Study Participants 120 What was tested Tazalok monotherapy (60 women) vs Vitex derivative monotherapy (60 women), each for 3 months Open access Yes Read the paper [doi.org/10.18370/2309-4117.2020.55.79-89](https://doi.org/10.18370/2309-4117.2020.55.79-89) Original abstract Breast dishormonal diseases and premenstrual syndrome (PMS) have a common pathogenetic mechanism: hyperprolactinemia, decreased progesterone levels, thyroid dysfunction, increased cortisol including as a result of stress, dysphoric disorders.Purpose of the study was to optimize monotherapy of breast dishormonal diseases in combination with PMS with phytoselective complex Tazalok™ and to compare the clinical efficacy with traditional therapy with Vitex agnus-castus derivative.Materials and methods. 120 women aged 22–39 years were observed into 2 groups: group I – 60 patients who received monotherapy Tazalok™ for 3 months; group II – 60 patients who received monotherapy with derivative of Vitex agnus-castus. Data analysis was performed after 1 and 3 months of treatment. Sex hormones, thyroid, gonadotropic hormones levels were determined. Ultrasound examination with color Doppler flow mapping of mammary glands, pelvic organs, and thyroid was performed. Dysphoric disorders were assessed on the Beck depression scale, pain was assessed on the visual-analog scale (VAS).Results. Group I showed an improvement in hormonal profile, reduction of subjective complaints after 1 month, in group II there was mainly a decrease in prolactin and relative normalization of follicle-stimulating hormone, luteinizing hormone; PMS complaints persisted. By 3 months patients in group I had normalization of all hormonal parameters, including cortisol, thyroid hormones, decreased pathological vascularization of mammary glands, thyroid, and pelvic organs, and a significant reduction in the Beck depressive score and VAS. In group II there was no normalization of cortisol, thyroid hormones, significantly reduced levels of progesterone and luteinizing hormone compared to group I, there was pathological vascularization in the thyroid gland, uterus. Dysphoric disorders decreased slightly, pain syndrome on the VAS decreased moderately, but the score was higher than among women taking Tazalok™.Conclusions. Tazalok™ directly affects reproductive system and balance of stress hormones, has a therapeutic effect on the thyroid gland. Under its action sonographic picture of hormone-dependent organs was normalized in contrast to the Vitex agnus-castus derivative. Tazalok™ has a pronounced effect on dysphoric disorders of PMS, helps to normalize the neuropsychological and cognitive state, to prevent of psychosomatic disorders. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Stress](https://niyora.com/research/topics/symptom-stress/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Thyroid disorders](https://niyora.com/research/topics/comorbidity-thyroid/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2025 How common is PMS in Chinese teenage girls, and what factors are linked to it? Randomised trial, 2026 Does education about PMS symptoms help reduce pain and stress? Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? 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