---
title: Is leptin hormone involved in causing or worsening PMS? | Niyora
description: Possibly. Two of three studies found higher leptin in women with PMS, but results were mixed and conflicting. We cannot yet say if leptin causes PMS or just m
url: https://niyora.com/research/papers/plasma-leptin-and-premenstrual-syndrome-a-review-2017/
---

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- Is leptin hormone involved in causing or worsening PMS?

Case-control study, 2017

# Is leptin hormone involved in causing or worsening PMS?

Possibly. Two of three studies found higher leptin in women with PMS, but results were mixed and conflicting. We cannot yet say if leptin causes PMS or just marks symptom severity.

 Early or limited evidence

181 participants across three studies in this review.

## What they did

Literature review of published studies. Researchers searched databases for studies examining leptin and PMS and identified three studies with a combined 181 participants.

## What they found

Two out of three studies found higher leptin levels in women with PMS. However, the three studies gave conflicting results about leptin levels during the luteal phase and correlations between leptin, estradiol, and progesterone levels.

## What it means for you

Leptin, a hormone affecting hunger and reproduction, might have a role in PMS and could mark symptom severity. The evidence is weak and inconsistent. A major limitation is only three small studies were found and they disagreed with each other. Much more research is needed.

3

Studies reviewed

181

Total participants across studies

2

Studies finding higher leptin in PMS (of 3)

## About the study

Original title Plasma Leptin and Premenstrual Syndrome: A Review Authors Nicolau ZFM, Bezerra AG, Polesel DN et al. Journal Obstetrical & gynecological survey Year 2017 Study design Case-control study Participants 181 What was tested None (literature review). Read the paper [doi.org/10.1097/ogx.0000000000000502](https://doi.org/10.1097/ogx.0000000000000502)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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