---
title: Do brain chemicals that affect mood change during the menstrual cycle in women with PMS?
description: In 12 women with PMS, the enzymes that break down these brain chemicals did not show clear changes across the cycle, unlike what was found in women without PM
url: https://niyora.com/research/papers/platelet-monoamine-oxidase-in-women-with-premenstrual-syndrome-1977/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Do brain chemicals that affect mood change during the menstrual cycle in women with PMS?

Study, 1977

# Do brain chemicals that affect mood change during the menstrual cycle in women with PMS?

In 12 women with PMS, the enzymes that break down these brain chemicals did not show clear changes across the cycle, unlike what was found in women without PMS.

 Early or limited evidence

12 women with PMS

## What they did

Measured two specific enzymes in 12 women with PMS throughout their menstrual cycle.

## What they found

There was no clear variation of the measured enzymes during the menstrual cycle in women with PMS. Previous studies found these enzyme levels declined before menstruation in women without PMS and in monkeys, but this study did not find that pattern.

## What it means for you

This suggests women with PMS might have a different enzyme pattern than women without PMS, which could help explain their symptoms. However, the study only included 12 women, so the findings may not apply to all women.

12

Women with PMS studied

## About the study

Original title Platelet monoamine oxidase in women with premenstrual syndrome Authors Feine R, Belmaker RH, Rimon R et al. Journal Neuropsychobiology Year 1977 Study design Study Participants 12 What was tested None Read the paper [doi.org/10.1159/000117594](https://doi.org/10.1159/000117594)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗