--- title: Can we predict which women with PMDD will benefit from leuprolide treatment? description: Yes, likely. Women whose daily mood ratings show more regular patterns (less variable day-to-day) before treatment are more likely to respond to leuprolide. T url: https://niyora.com/research/papers/predicting-response-to-leuprolide-of-women-with-premenstrual-dysphoric-disorder-2011/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Can we predict which women with PMDD will benefit from leuprolide treatment? Non-randomised trial, 2011 # Can we predict which women with PMDD will benefit from leuprolide treatment? Yes, likely. Women whose daily mood ratings show more regular patterns (less variable day-to-day) before treatment are more likely to respond to leuprolide. This can be determined from mood records taken over less than 3 months. Early or limited evidence 33 women with PMDD who responded to leuprolide and 12 who did not, from clinical trials. ## What they did Comparison study of 33 women with PMDD who responded well to leuprolide and 12 who did not. Researchers looked at daily self-ratings of sadness, anxiety, and irritability taken before treatment. They used statistical tests to measure how regular each person's mood pattern was. ## What they found Women who responded to leuprolide had significantly more regular mood patterns before treatment than those who didn't respond (P less than 0.005 to 0.002). The statistical measures could identify responders from non-responders with high accuracy. Average symptom levels were similar between groups, but the pattern of symptoms differed. About 60-70% of women with PMDD respond to leuprolide. ## What it means for you Before prescribing leuprolide, doctors may be able to predict who will benefit by examining mood pattern regularity over a few months. This could help avoid unnecessary hormone treatment. The study is limited by small sample size and lack of a randomized comparison group. 33 Women who responded to leuprolide 12 Women who did not respond 60-70% Overall response rate to leuprolide ## About the study Original title Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics Authors Pincus SM, Alam S, Rubinow DR et al. Journal Journal of psychiatric research Year 2011 Study design Non-randomised trial Participants 33 What was tested Leuprolide acetate (a hormone medication that suppresses ovarian function), 3 months duration. Open access Yes Read the paper [doi.org/10.1016/j.jpsychires.2010.07.006](https://doi.org/10.1016/j.jpsychires.2010.07.006) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 What are the best treatments for PMDD and PMS? Guideline, 2023 How are GnRH agonists used to treat PMDD that doesn't respond to standard medications? Review, 2022 What causes severe PMS and what treatments work? Systematic review, 2022 What are the best treatments for PMDD and PMS? Review, 2018 What are the most effective treatments for premenstrual syndrome and PMDD? Review, 2015 What do we know about PMS and PMDD and how are they treated? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗