---
title: What are the most effective treatments for premenstrual syndrome and PMDD?
description: Serotonin reuptake inhibitors and contraceptives with shortened or no hormone-free interval are the most effective treatments. Some women who do not respond m
url: https://niyora.com/research/papers/premenstrual-disorders-2018/
---

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- What are the most effective treatments for premenstrual syndrome and PMDD?

Review, 2018

# What are the most effective treatments for premenstrual syndrome and PMDD?

Serotonin reuptake inhibitors and contraceptives with shortened or no hormone-free interval are the most effective treatments. Some women who do not respond may benefit from GnRH agonist treatment.

 Strong study design

Women with premenstrual disorders (review article)

## What they did

Researchers reviewed scientific evidence on treatments for premenstrual disorders including PMS, PMDD, and premenstrual worsening of other medical conditions.

## What they found

Serotonin reuptake inhibitors and contraceptives with shortened to no hormone-free interval are the most efficacious treatments for PMS and PMDD. Women who do not respond to these and other interventions may benefit from gonadotropin-releasing hormone agonist treatment.

## What it means for you

These treatments have the most evidence showing they work. The underlying causes are still being studied, and individual response varies between women.

## About the study

Original title Premenstrual disorders Authors Yonkers KA, Simoni MK Journal American journal of obstetrics and gynecology Year 2018 Study design Review What was tested Not applicable (review of treatments) Read the paper [doi.org/10.1016/j.ajog.2017.05.045](https://doi.org/10.1016/j.ajog.2017.05.045)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Cognitive behavioral therapy](https://niyora.com/research/topics/treatment-cbt/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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