---
title: What causes PMDD and how can it be treated? | Niyora
description: The review suggests PMDD is caused by problems with how the brain's serotonin system works. Medications called serotonin reuptake inhibitors appear effective
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-diagnostic-and-therapeutic-approach-1997/
---

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- What causes PMDD and how can it be treated?

Review, 1997

# What causes PMDD and how can it be treated?

The review suggests PMDD is caused by problems with how the brain's serotonin system works. Medications called serotonin reuptake inhibitors appear effective for treatment.

 Early or limited evidence

Review article, not applicable

## What they did

Review article that discussed how the brain and hormonal system interact in PMDD, reviewed the new diagnostic criteria, and summarized what is known about the cause and treatment.

## What they found

The review identifies altered serotonin regulation as a promising area for understanding PMDD. Serotonin reuptake inhibitor medications showed efficacy in treating PMDD.

## What it means for you

Current understanding suggests PMDD may be linked to how the brain handles serotonin, and medications that affect serotonin may help. This summarizes existing knowledge rather than presenting new research data.

## About the study

Original title [Premenstrual dysphoric disorder: diagnostic and therapeutic approach] Authors Guedj F Journal La Revue du praticien Year 1997 Study design Review What was tested Review article, not applicable Read the paper [https://pubmed.ncbi.nlm.nih.gov/9453190/](https://pubmed.ncbi.nlm.nih.gov/9453190/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2008

What treatments work best for PMS and PMDD?

Randomised trial, 2003

Are SSRI antidepressants effective for PMDD?

Randomised trial, 1999

Do SSRIs reduce premenstrual dysphoria symptoms?

Randomised trial, 1995

Does fluoxetine help premenstrual dysphoria?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Cohort study, 2019

Do SSRIs help women who have both PMS and panic disorder?

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