---
title: Can the antidepressant fluoxetine help teenage girls with PMDD?
description: In these 3 case reports, fluoxetine fully resolved PMDD symptoms in teenage girls treated for 2 years, but with no control group this cannot prove the drug ca
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-in-adolescents-case-reports-of-treatment-with-2005/
---

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- Can the antidepressant fluoxetine help teenage girls with PMDD?

Randomised trial, 2005

# Can the antidepressant fluoxetine help teenage girls with PMDD?

In these 3 case reports, fluoxetine fully resolved PMDD symptoms in teenage girls treated for 2 years, but with no control group this cannot prove the drug caused the improvement.

 Early or limited evidence

3 adolescent girls with PMDD.

## What they did

Doctors described 3 adolescent girls with PMDD who were treated with fluoxetine for 2 years, and reviewed existing clinical trials of fluoxetine for PMDD in adult women.

## What they found

All 3 teenagers had complete resolution of their PMDD symptoms after 2 years of fluoxetine treatment. The authors note this adds to evidence from adult trials supporting fluoxetine's effectiveness.

## What it means for you

This may support using fluoxetine for severe, disabling PMDD in teenagers, but it is based on only 3 cases with no placebo comparison. The authors themselves call for a proper randomized placebo-controlled trial in adolescents.

3

Girls treated

2 years

Treatment duration

## About the study

Original title Premenstrual dysphoric disorder in adolescents: case reports of treatment with fluoxetine and review of the literature Authors Silber TJ, Valadez-Meltzer A Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Year 2005 Study design Randomised trial Participants 3 What was tested Fluoxetine, taken for 2 years. Read the paper [doi.org/10.1016/j.jadohealth.2004.12.006](https://doi.org/10.1016/j.jadohealth.2004.12.006)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/)

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