---
title: What are the most effective treatments for PMDD? | Niyora
description: According to this literature review, SSRIs (antidepressants) and cognitive-behavioral therapy are the most commonly recommended first-line treatments. Birth c
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-pmdd-drug-and-psychotherapeutique-management-a-2024/
---

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- What are the most effective treatments for PMDD?

Review, 2024

# What are the most effective treatments for PMDD?

According to this literature review, SSRIs (antidepressants) and cognitive-behavioral therapy are the most commonly recommended first-line treatments. Birth control pills with drospirenone are also effective.

 Strong study design

Literature review of various studies on PMDD treatments (no new participants)

## What they did

Literature review of 32 articles published between June and July 2021 from databases including PubMed, Scopus, and Cochrane. Researchers searched for information on drug and psychotherapy treatments for PMDD and their effectiveness.

## What they found

SSRIs are first-line treatment with these dose ranges: sertraline 50-150 mg per day, fluoxetine 10-20 mg per day, escitalopram 10-20 mg per day, paroxetine 12.5-25 mg per day. Birth control pills with drospirenone are first or second line treatments. Cognitive behavioral therapy showed positive results in reducing the functional impact of PMDD.

## What it means for you

Women with PMDD have several evidence-based treatment options including medications and therapy. SSRIs are the primary drug choice recommended. This review synthesizes existing research but only searched literature through July 2021, so recent studies may be missed.

32

articles reviewed

50-150 mg/day

sertraline dose range

10-20 mg/day

fluoxetine dose range

## About the study

Original title [Premenstrual dysphoric disorder (PMDD): Drug and psychotherapeutique management, a literature review] Authors Marais-Thomas H, Chapelle F, de Vaux-Boitouzet V et al. Journal L'Encephale Year 2024 Study design Review What was tested SSRIs, drospirenone birth control, and cognitive behavioral therapy Read the paper [doi.org/10.1016/j.encep.2023.08.007](https://doi.org/10.1016/j.encep.2023.08.007)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[Cognitive behavioral therapy](https://niyora.com/research/topics/treatment-cbt/)[Psychotherapy, counselling and education](https://niyora.com/research/topics/treatment-psychotherapy/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Systematic review, 2012

How effective are cognitive-behavioral therapy and antidepressants for PMS and PMDD?

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What are PMS and PMDD and how should they be diagnosed and treated?

Review, 2016

How common are PMS and PMDD, and what are the best treatments?

Study, 2022

What are the symptoms, causes, and treatments of PMS and PMDD?

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