---
title: What is PMDD and how can it be treated? | Niyora
description: PMDD is a severe set of mood and physical symptoms linked to estrogen that appear during the luteal phase and disappear within one week after menstruation. Tr
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-review-of-actual-findings-about-mental-disorders-2010/
---

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- What is PMDD and how can it be treated?

Review, 2010

# What is PMDD and how can it be treated?

PMDD is a severe set of mood and physical symptoms linked to estrogen that appear during the luteal phase and disappear within one week after menstruation. Treatment with SSRIs (antidepressants) shows promise but works best as part of a multidisciplinary approach.

 Early or limited evidence

Not a primary study; review of existing research

## What they did

This is a review of existing research on PMDD, its diagnostic criteria, relationship to mood disorders, and treatment options including SSRIs.

## What they found

PMDD appears as subjectively unpleasant mental and physical symptoms during the luteal phase and disappears by one week after menstruation. It is now classified as a separate psychiatric diagnosis in DSM-IV-TR but is not specifically included in ICD-10. SSRIs are discussed as an effective treatment option.

## What it means for you

PMDD is recognized as a serious menstrual cycle-related condition distinct from regular PMS, but diagnostic criteria differ between classification systems worldwide. This inconsistency affects how the condition is recognized and treated globally. Treatment requires a multidisciplinary approach beyond antidepressants alone.

3

Classification systems discussed

## About the study

Original title Premenstrual dysphoric disorder--review of actual findings about mental disorders related to menstrual cycle and possibilities of their therapy Authors Zukov I, Ptácek R, Raboch J et al. Journal Prague medical report Year 2010 Study design Review What was tested Treatment options reviewed, particularly SSRIs Read the paper [https://pubmed.ncbi.nlm.nih.gov/20359434/](https://pubmed.ncbi.nlm.nih.gov/20359434/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Randomised trial, 2000

Does sertraline improve how women with PMDD feel and function?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Study, 2026

What treatments work for PMDD?

Cohort study, 2022

What are PMS and PMDD and how should they be diagnosed and treated?

Cohort study, 2012

How quickly does fluoxetine start working for PMDD symptoms?

Review, 2012

Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause?

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