--- title: Does premenstrual worsening of panic disorder increase suicide risk in women? description: Yes. Women with panic disorder who experienced premenstrual worsening had higher suicide risk scores and were more likely to be considered suicidal than women url: https://niyora.com/research/papers/premenstrual-exacerbation-and-suicidal-behavior-in-patients-with-panic-disorder-2000/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does premenstrual worsening of panic disorder increase suicide risk in women? Survey study, 2000 # Does premenstrual worsening of panic disorder increase suicide risk in women? Yes. Women with panic disorder who experienced premenstrual worsening had higher suicide risk scores and were more likely to be considered suicidal than women whose panic did not worsen premenstrually. This was independent of depression. Early or limited evidence 28 women with panic disorder and premenstrual exacerbation, and 42 women without premenstrual exacerbation ## What they did Cross-sectional study comparing 28 women with panic disorder and premenstrual exacerbation to 42 women with panic disorder without premenstrual exacerbation. They rated panic symptoms, depression severity, and suicide risk using standardized scales. ## What they found Patients with premenstrual exacerbation of panic disorder had significantly higher suicide risk scores on standardized measures compared to those without premenstrual exacerbation. They were more likely to be classified as suicidal. The researchers suggest this increased suicide risk may be independent of major depression. ## What it means for you If you have panic disorder and notice it worsens before your period, that pattern may be associated with increased suicide risk and warrants careful monitoring. A major limitation is the small sample and observational design, so we cannot be certain the premenstrual worsening directly causes the increased risk. 28 Women with premenstrual panic exacerbation 42 Women without premenstrual panic exacerbation ## About the study Original title Premenstrual exacerbation and suicidal behavior in patients with panic disorder Authors Başoğlu C, Cetin M, Semiz UB et al. Journal Comprehensive psychiatry Year 2000 Study design Survey study Participants 42 What was tested None. Observational comparison. Read the paper [doi.org/10.1016/s0010-440x(00)90141-x](https://doi.org/10.1016/s0010-440x(00)90141-x) ## Topics [Anxiety disorders and OCD](https://niyora.com/research/topics/comorbidity-anxiety-disorders/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Schizophrenia and psychosis](https://niyora.com/research/topics/comorbidity-psychosis/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Suicidality](https://niyora.com/research/topics/symptom-suicidality/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Survey study, 2004 How common is PMS and premenstrual worsening of psychiatric symptoms in women with mental health disorders? Review, 2024 What is premenstrual exacerbation and how does it affect different psychiatric illnesses? Systematic review, 2022 Do mental health disorders get worse during the menstrual cycle? Cohort study, 2023 Are premenstrual disorders linked to depression, anxiety, and self-harm in teenage girls? Review, 2002 What are the reproductive-related mood disorders and how are they connected? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗