---
title: What causes PMS and how is it treated? | Niyora
description: The exact cause is unknown, but researchers believe it involves an imbalance between hormones and brain chemicals. This summary covers the leading theories ab
url: https://niyora.com/research/papers/premenstrual-syndrome-2002-1e4983/
---

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- What causes PMS and how is it treated?

Cohort study, 2002

# What causes PMS and how is it treated?

The exact cause is unknown, but researchers believe it involves an imbalance between hormones and brain chemicals. This summary covers the leading theories about what causes PMS and the treatments that work best.

 Early or limited evidence

This is a literature review, not an original study

## What they did

This is a literature review summarizing the major theories about what causes PMS and the treatment approaches supported by high-quality research studies.

## What they found

The review identifies that PMS involves a disruption in the balance between sex hormones and brain neurotransmitters. It discusses the leading theories and available treatments based on evidence from well-designed studies but does not provide specific data.

## What it means for you

PMS clearly affects millions of women and varies widely between individuals. The exact biological mechanism remains unknown, and the wide variety of symptoms and their cyclic nature make PMS challenging to understand and treat.

## About the study

Original title Premenstrual syndrome Authors Gianetto-Berruti A, Feyles V Journal Minerva ginecologica Year 2002 Study design Cohort study What was tested None Read the paper [https://pubmed.ncbi.nlm.nih.gov/12032448/](https://pubmed.ncbi.nlm.nih.gov/12032448/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2007

What treatments work for premenstrual syndrome?

Randomised trial, 2003

What treatments work for PMS and PMDD?

Review, 2002

What treatments work best for PMS and PMDD?

Review, 2001

What are PMS and PMDD, and how are they treated?

Study, 1997

What medications work best for treating PMS?

Randomised trial, 2006

Do different types of PMS symptoms respond better to different medicines?

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