--- title: Does progesterone suppository help premenstrual syndrome? | Niyora description: No, progesterone vaginal suppositories (200 mg) did not reduce PMS symptoms more than placebo. This was a small study of 30 women. url: https://niyora.com/research/papers/premenstrual-syndrome-a-double-blind-placebo-controlled-study-of-treatment-with-1987/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does progesterone suppository help premenstrual syndrome? Randomised trial, 1987 # Does progesterone suppository help premenstrual syndrome? No, progesterone vaginal suppositories (200 mg) did not reduce PMS symptoms more than placebo. This was a small study of 30 women. Moderate study design 30 women with premenstrual syndrome ## What they did 30 women with PMS took progesterone vaginal suppositories (200 mg) during one cycle and placebo during another cycle in a double-blind study. Researchers compared physical, psychological, and behavioral symptoms between the progesterone and placebo cycles. ## What they found There were no significant differences in physical, psychological, or behavioral symptoms when progesterone cycles were compared with placebo or baseline cycles. ## What it means for you Progesterone suppositories don't appear to work better than placebo for PMS. This was one of the first controlled studies of progesterone treatment, challenging earlier uncontrolled studies that suggested it helped. The study was small, so more research is needed. 30 women studied 200 mg progesterone dose ## About the study Original title Premenstrual syndrome: a double blind placebo controlled study of treatment with progesterone vaginal suppositories Authors Andrea J. Rapkin, Lin Chang, Anthony E. Reading Journal Journal of Obstetrics and Gynaecology Year 1987 Study design Randomised trial Participants 30 What was tested Progesterone vaginal suppositories 200 mg Read the paper [doi.org/10.3109/01443618709068522](https://doi.org/10.3109/01443618709068522) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Randomised trial, 2020 Does progesterone therapy help premenstrual syndrome in women with PCOS? Randomised trial, 2013 Does progesterone reduce PMS symptoms in women with polycystic ovary syndrome? Case report, 2012 How can doctors tell the difference between severe PMS and bipolar disorder? Survey study, 2005 Does drospirenone hormone therapy reduce weight gain and PMS-like symptoms? Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Survey study, 2022 What causes PMS and PMDD and what new treatments are being studied? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗