---
title: Is buspirone as good as fluoxetine for treating PMS? | Niyora
description: Both medicines helped reduce PMS symptoms, and there was no clear difference between them. However, larger and more rigorous studies are needed to confirm thi
url: https://niyora.com/research/papers/premenstrual-syndrome-a-single-blind-study-of-treatment-with-buspirone-versus-2013/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Is buspirone as good as fluoxetine for treating PMS?

Randomised trial, 2013

# Is buspirone as good as fluoxetine for treating PMS?

Both medicines helped reduce PMS symptoms, and there was no clear difference between them. However, larger and more rigorous studies are needed to confirm this.

 Moderate study design

100 women in reproductive age who met PMS diagnostic criteria

## What they did

100 women with PMS were randomly divided into two groups. One took fluoxetine 20 mg per day; the other took buspirone 10 mg per day. Both took their medicine for 2 months. Women reported symptoms before treatment started, after 1 month, and after 2 months. This was a single-blind study.

## What they found

Both fluoxetine and buspirone were effective at reducing PMS symptoms during the 2-month treatment period. There was no clear difference in how well they worked.

## What it means for you

Buspirone and fluoxetine may both help with PMS, and buspirone might be useful because it has fewer side effects. This study was small, single-blind, and had no placebo control group. Larger double-blind studies are needed to confirm these findings.

100

Women studied

20 mg daily

Fluoxetine dose

10 mg daily

Buspirone dose

## About the study

Original title Premenstrual syndrome: a single-blind study of treatment with buspirone versus fluoxetine Authors Nazari H, Yari F, Jariani M et al. Journal Archives of gynecology and obstetrics Year 2013 Study design Randomised trial What was tested Fluoxetine 20 mg daily or buspirone 10 mg daily for 2 months Read the paper [doi.org/10.1007/s00404-012-2594-x](https://doi.org/10.1007/s00404-012-2594-x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2015

What treatments work best for PMDD and PMS?

Systematic review, 2007

What treatments work for premenstrual syndrome?

Randomised trial, 2004

What medications work for PMDD when taken only during the second half of the menstrual cycle?

Review, 2002

What treatments work best for PMS and PMDD?

Study, 1997

What medications work best for treating PMS?

Non-randomised trial, 2020

What treatments help premenstrual syndrome?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗